中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2010年
3期
152-155
,共4页
滕家安%秦俭%梁远%王仁生%汤春园
滕傢安%秦儉%樑遠%王仁生%湯春園
등가안%진검%량원%왕인생%탕춘완
2型糖尿病%结直肠癌%临床研究
2型糖尿病%結直腸癌%臨床研究
2형당뇨병%결직장암%림상연구
Type 2 diabetes mellitus%Colorectal cancer%Clinical study
目的:探讨2型糖尿病(T2DM)与结直肠癌发病和转移的关系.方法:收集广西医科大学第一附属医院2001年1月至2006年12月间收治的结直肠癌患者852例和非肿瘤患者940例的临床资料.比较两组在性别、肿瘤部位、糖尿病痛程和肝转移等方面的差异,并对相关危险因素进行分析.结果:,T2DM患者结直肠癌发病的危险显著高于非T2DM患者,其OR值为2.466,男性T2DM患者发生结直肠癌的危险高于女性,差异无统计学意义(OR值2.775 vs 2.070,P=0.394).患有左半结肠癌的患者发生T2DM的比例最高,但与患有右半结肠癌和直肠癌者无显著性差异.T2DM病程在10~20年组发生结直肠癌的危险性最高,其OR值为4.696.T2DM合并结直肠癌患者发生肝脏转移危险性高于非T2DM合并结直肠癌患者,其OR值为2.888.结论:T2DM可能是结直肠癌发生的危险因素之一,在T2DM病程小于20年以内这种危险性随着病程的增加而增加;T2DM合并结直肠癌患者更容易发生肝脏转移.
目的:探討2型糖尿病(T2DM)與結直腸癌髮病和轉移的關繫.方法:收集廣西醫科大學第一附屬醫院2001年1月至2006年12月間收治的結直腸癌患者852例和非腫瘤患者940例的臨床資料.比較兩組在性彆、腫瘤部位、糖尿病痛程和肝轉移等方麵的差異,併對相關危險因素進行分析.結果:,T2DM患者結直腸癌髮病的危險顯著高于非T2DM患者,其OR值為2.466,男性T2DM患者髮生結直腸癌的危險高于女性,差異無統計學意義(OR值2.775 vs 2.070,P=0.394).患有左半結腸癌的患者髮生T2DM的比例最高,但與患有右半結腸癌和直腸癌者無顯著性差異.T2DM病程在10~20年組髮生結直腸癌的危險性最高,其OR值為4.696.T2DM閤併結直腸癌患者髮生肝髒轉移危險性高于非T2DM閤併結直腸癌患者,其OR值為2.888.結論:T2DM可能是結直腸癌髮生的危險因素之一,在T2DM病程小于20年以內這種危險性隨著病程的增加而增加;T2DM閤併結直腸癌患者更容易髮生肝髒轉移.
목적:탐토2형당뇨병(T2DM)여결직장암발병화전이적관계.방법:수집엄서의과대학제일부속의원2001년1월지2006년12월간수치적결직장암환자852례화비종류환자940례적림상자료.비교량조재성별、종류부위、당뇨병통정화간전이등방면적차이,병대상관위험인소진행분석.결과:,T2DM환자결직장암발병적위험현저고우비T2DM환자,기OR치위2.466,남성T2DM환자발생결직장암적위험고우녀성,차이무통계학의의(OR치2.775 vs 2.070,P=0.394).환유좌반결장암적환자발생T2DM적비례최고,단여환유우반결장암화직장암자무현저성차이.T2DM병정재10~20년조발생결직장암적위험성최고,기OR치위4.696.T2DM합병결직장암환자발생간장전이위험성고우비T2DM합병결직장암환자,기OR치위2.888.결론:T2DM가능시결직장암발생적위험인소지일,재T2DM병정소우20년이내저충위험성수착병정적증가이증가;T2DM합병결직장암환자경용역발생간장전이.
Objective: To investigate the relationship between type 2 diabetes mellitus (T2DM) and the pathogenesis and metastasis of colorectal cancer. Methods: A case-control study was performed to compare 852 colorectal cancer patients with 940 controls (patients without cancer) recruited from 2001 to 2006, with respect to their sex, cancer subsite, the course of T2DM, hepatic metastasis, smoking and drinking. Correlated risk factors were analyzed. Results: The risk of colorectal cancer was increased in patients with T2DM and the relative risk (OR) was 2.466. The OR of male patients was higher than that of female patients, but with no significant difference (2.775 vs 2.070, P=0.394). The incidence of T2DM in patients with left hemicolon cancer was higher than that in those with right hemicolon cancer and rectal cancer, but with no significant difference between them. The colorectal cancer risk in T2DM patients with a DM course of 10 ~ 20 years was the highest, and the OR was 4.696. The rate of hepatic metastasis was higher in T2DM patients with colorectal cancer than that in celorectal cancer patients without T2DM and the OR was 2.888. Conclusion: T2DM may be one of the important pathogenic risk factors for colorectal cancer. The OR is increased with the extension of DM course within 20 years. Colorectal cancer patients with T2DM may be more prone to hepatic metastasis.