CAJ | 학술논문

γδT细胞是T淋巴细胞中一类数量比较少的细胞,不受MHC I、Ⅱ类分子以及相关抗原肽配体限制,可直接识别抗原,分泌细胞因子溶解靶细胞,具有广泛的抗肿瘤活性.在骨肉瘤患者中,γδT细胞可通过识别骨肉瘤细胞表面相关抗原,溶解杀灭肿瘤细胞.未来以γδT细胞为基础的细胞免疫疗法联合手术、化疗等方法可在较大程度上提高骨肉瘤患者生存率.
γδT세포시T림파세포중일류수량비교소적세포,불수MHC I、Ⅱ류분자이급상관항원태배체한제,가직접식별항원,분비세포인자용해파세포,구유엄범적항종류활성.재골육류환자중,γδT세포가통과식별골육류세포표면상관항원,용해살멸종류세포.미래이γδT세포위기출적세포면역요법연합수술、화료등방법가재교대정도상제고골육류환자생존솔.
γδT lymphocytes,a numerically small subset of T lymphocytes,have been shown to directly recognize protein antigens without restriction by polymorphic MHC class I or class Ⅱ molecules and their asso-ciated peptide ligands,secrete cytokines,kill tumor cells and display cytolytie activity against various tumors.In osteosarconla patients,γδT lymphocytes can recognize antigens expressed on the surface of osteosarcoma cells,lyse and kill tumor cells.Combined with converntional chemotherapy and surgery,the new γδT lympho-cytes-based cell immunotherapy of osteosarcoma can increase the survival rate greatly.