国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2010年
10期
742-745
,共4页
糖尿病%肿瘤%高胰岛素血症%胰岛素样生长因子Ⅰ
糖尿病%腫瘤%高胰島素血癥%胰島素樣生長因子Ⅰ
당뇨병%종류%고이도소혈증%이도소양생장인자Ⅰ
Diabetes mellitus%Neoplasms%Hyperinsulinism%Insulin-like growth factor Ⅰ
糖尿病与肿瘤是密切相关的慢性疾病.流行病学研究表明,糖尿病患者不仅罹患胰腺癌、肝癌、乳腺癌、结直肠癌和尿道癌等肿瘤的风险增高,且其死亡风险也相应增加.胰岛素在新陈代谢和有丝分裂中起重要作用.在肿瘤发生发展中,胰岛素可通过受体和受体后水平活化机制发挥作用,故高胰岛素血症是最可能导致糖尿病患者发生肿瘤的危险因素.此外,降糖药物、肥胖、高血糖症和氧化应激也可能是糖尿病患者肿瘤危险性增高的因素.
糖尿病與腫瘤是密切相關的慢性疾病.流行病學研究錶明,糖尿病患者不僅罹患胰腺癌、肝癌、乳腺癌、結直腸癌和尿道癌等腫瘤的風險增高,且其死亡風險也相應增加.胰島素在新陳代謝和有絲分裂中起重要作用.在腫瘤髮生髮展中,胰島素可通過受體和受體後水平活化機製髮揮作用,故高胰島素血癥是最可能導緻糖尿病患者髮生腫瘤的危險因素.此外,降糖藥物、肥胖、高血糖癥和氧化應激也可能是糖尿病患者腫瘤危險性增高的因素.
당뇨병여종류시밀절상관적만성질병.류행병학연구표명,당뇨병환자불부리환이선암、간암、유선암、결직장암화뇨도암등종류적풍험증고,차기사망풍험야상응증가.이도소재신진대사화유사분렬중기중요작용.재종류발생발전중,이도소가통과수체화수체후수평활화궤제발휘작용,고고이도소혈증시최가능도치당뇨병환자발생종류적위험인소.차외,강당약물、비반、고혈당증화양화응격야가능시당뇨병환자종류위험성증고적인소.
Diabetes and cancer, two heterogeneous multffactorial severe chronic diseases, are closely related. Epidemiological studies clearly indicate that diabetics have an increased risk and mortality of several cancers, including cancers of the pancreas, liver, breast, colorectum and urinary tract. Insulin is a growth factor with preeminent metabolic and mitogenic effects and functions at both receptor and post-receptor level during cancer development. As a result, hyperinsulinemia is the most likely cause of cancers among diabetic patients. However, anti-diabetic drugs, obesity, hyperglycemia, and increased oxidative stress may also contribute to the increased cancer risk among diabetics.
