CAJ | 학술논문

基因载体是将治疗基因导入肿瘤细胞的载体，在基因治疗中起关键作用。目前常用的基因治疗载体分为生物载体和非生物载体两大类。生物载体包括病毒载体、细菌载体和干细胞载体。研究显示生物载体虽然靶向性好，转导效率高但存在遗传安全隐患；非生物载体包括脂质体和纳米材料类载体，这类载体制备简单，安全可控但转导效率低。建立安全有效的脑胶质瘤治疗基因导入系统，寻找具有良好靶向性的基因载体，成为研究者们关注的问题。
기인재체시장치료기인도입종류세포적재체，재기인치료중기관건작용。목전상용적기인치료재체분위생물재체화비생물재체량대류。생물재체포괄병독재체、세균재체화간세포재체。연구현시생물재체수연파향성호，전도효솔고단존재유전안전은환；비생물재체포괄지질체화납미재료류재체，저류재체제비간단，안전가공단전도효솔저。건립안전유효적뇌효질류치료기인도입계통，심조구유량호파향성적기인재체，성위연구자문관주적문제。
The vectors play an important role in gene therapy by transporting the therapy genes into target tumor cells. At present there are mainly two kinds of gene vectors, including biological and non-biological vectors. Biological vectors, including virus, bacteria and stem cells, have good target activity and can efficiently delivery the genes into target tumor cells, but have potential genetic hazards. However, non-biological vectors, including liposomes and nanoparticles, can be simplely prepared with high genetic safety, but they can not transport the genes efficiently. Therefore, establishing safe and effective malignant glioma gene treatment system and finding gene vectors with good target activity become the research focus.