CAJ | 학술논문

目的提高对Hyper-CVAD方案治疗成年人T淋巴母细胞淋巴瘤(TLL)的认识.方法总结7例采用Hyper-CVAD方案治疗的成年TLL患者的转归.结果 7例患者中,1例因未完成首次化疗并未行相关后续治疗最后死亡;1例自体干细胞移植前骨髓获得完全缓解,移植后骨髓复发;3例一直获得完全缓解;2例患者复发后由于配型和经济原因,未实施异基因骨髓移植,使用ICE方案及重复原方案,疗效均不佳,自动放弃继续治疗.结论成年人TLL应早期发现、早期治疗,并重视一些特异性的辅助检查,明确治疗的选择与淋巴瘤分期无关及腰椎穿刺鞘内注射的重要性,化疗周期应规律,确保足程化疗次数,纵隔占位者可在接受4个周期Hyper-CVAD化疗后对纵隔肿块直径＞5 cm的患者进行放疗,最后选择合适的移植方式进行移植.
목적 제고대Hyper-CVAD방안치료성년인T림파모세포림파류(TLL)적인식.방법 총결7례채용Hyper-CVAD방안치료적성년TLL환자적전귀.결과 7례환자중,1례인미완성수차화료병미행상관후속치료최후사망;1례자체간세포이식전골수획득완전완해,이식후골수복발;3례일직획득완전완해;2례환자복발후유우배형화경제원인,미실시이기인골수이식,사용ICE방안급중복원방안,료효균불가,자동방기계속치료.결론 성년인TLL응조기발현、조기치료,병중시일사특이성적보조검사,명학치료적선택여림파류분기무관급요추천자초내주사적중요성,화료주기응규률,학보족정화료차수,종격점위자가재접수4개주기Hyper-CVAD화료후대종격종괴직경＞5 cm적환자진행방료,최후선택합괄적이식방식진행이식.
Objective To improve the recognition of treatment of adult T lymphoblastic lymphoma (TLL) with Hyper-CVAD regime.Methods The turnovers of 7 cases treated with Hyper-CVAD regime were summarized.Results Among the 7 cases,1 case died after the first unfinished chemotherapy,1 case gained complete remission before autologous stem cell transplantation but relapsed after transplantation,3 cases gained complete remission until now,2 cases without transplantation relapsed and then gave up following treatments after treating with ICE regime or the virgin regime,but the therapeutic effects were poor.Conclusions Adult TLL should get early chemotherapy treatments,and some special characteristics should be noted,the treatment does not relate to the stage,the chemotherapy treatment should be carried out regularly and enough,radiation of mediastinum mass can be applied after 4 cycles of Hyper-CVAD regime,choose suitable transplantation method.