CAJ | 학술논문

目的探讨代谢综合征(MS)在老年人良性前列腺增生(BPH)病程中的作用.方法 101例BPH患者分为单纯BPH组45例与合并MS的BPH组56例,分析体质量指数(BMI)、腰围、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBS)、胰岛素抵抗指数(HOMA-IR)等代谢性因素对BPH患者前列腺体积(PV)、血清前列腺特异性抗原(PSA)、国际前列腺症状评分(IPSS)、下尿路症状(LUTS)出现时间的影响.结果合并MS的BPH患者PV明显大于单纯BPH患者(t=3.22,P=0.003),LUTS出现时间长于后者(t=2.02,P=0.046).超重和肥胖的BPH患者PV明显大于正常体质量组[分别为(49.44±26.83)ml与(38.10±10.64)ml,P=0.021;(51.7±22.2)ml与(38.10±10.64)ml,P=0.043]；腹型肥胖的BPH组患者PV明显大于非腹型肥胖的BPH患者组[(50.26±26.51)ml与(38.99±11.25)ml,P=0.005].低HDL-C水平组PV明显大于正常HDL-C水平组[(54.23±28.92)ml与(40.40±14.87) ml,P=0.009].FBS水平异常的BPH患者PV、PSA水平超过正常FBS水平者(t=3.17,2.41; P=0.035,0.013).合并胰岛素抵抗的BPH患者的PV明显大于胰岛素敏感者(t=3.43,P=0.001),LUTS出现时间在胰岛素抵抗组明显延长(t=3.58,P=0.001).PV与BMI (r=0.46,P=0.000)、FINS (r=0.42,P=0.001)、HOMA-IR (r=0.49,P=0.003)呈正相关；而与HDL-C(r=-0.38,P=0.000)呈负相关.多元逐步回归分析显示PV与HOMA-IR关系最密切.结论 MS对BPH的病程和发展具有明显的影响.
목적 탐토대사종합정(MS)재노년인량성전렬선증생(BPH)병정중적작용.방법 101례BPH환자분위단순BPH조45례여합병MS적BPH조56례,분석체질량지수(BMI)、요위、고밀도지단백담고순(HDL-C)、공복혈당(FBS)、이도소저항지수(HOMA-IR)등대사성인소대BPH환자전렬선체적(PV)、혈청전렬선특이성항원(PSA)、국제전렬선증상평분(IPSS)、하뇨로증상(LUTS)출현시간적영향.결과 합병MS적BPH환자PV명현대우단순BPH환자(t=3.22,P=0.003),LUTS출현시간장우후자(t=2.02,P=0.046).초중화비반적BPH환자PV명현대우정상체질량조[분별위(49.44±26.83)ml여(38.10±10.64)ml,P=0.021;(51.7±22.2)ml여(38.10±10.64)ml,P=0.043]；복형비반적BPH조환자PV명현대우비복형비반적BPH환자조[(50.26±26.51)ml여(38.99±11.25)ml,P=0.005].저HDL-C수평조PV명현대우정상HDL-C수평조[(54.23±28.92)ml여(40.40±14.87) ml,P=0.009].FBS수평이상적BPH환자PV、PSA수평초과정상FBS수평자(t=3.17,2.41; P=0.035,0.013).합병이도소저항적BPH환자적PV명현대우이도소민감자(t=3.43,P=0.001),LUTS출현시간재이도소저항조명현연장(t=3.58,P=0.001).PV여BMI (r=0.46,P=0.000)、FINS (r=0.42,P=0.001)、HOMA-IR (r=0.49,P=0.003)정정상관；이여HDL-C(r=-0.38,P=0.000)정부상관.다원축보회귀분석현시PV여HOMA-IR관계최밀절.결론 MS대BPH적병정화발전구유명현적영향.
Objective To explore the effect of metabolic syndrome (MS) on the occurrence and development of benign prostate hyperplasia (BPH).Methods 101 elderly BPH patients were divided into two groups:BPH (n = 45) and BPH with MS (n= 56)group.The effects of metabolic indexes,including body mass index (BMI),waist,high density lipoprotein cholesterol (HDL-C),fasting blood glucose (FBS) and insuline resistance index (H()MA-IR),on prostate volume(PV),prostate-specific antigen (PSA),international prostate symptom score (IPSS) and lower urinary tract symptoms (LUTS) were surveyed in BPH patients.Results BPH with MS group showed significantly higher values of PV (t = 3.22,P= 0.003)and longer course of LUTS (t= 2.02,P =0.046) than BPH group.The BPH patients with overweight and obesity had significantly higher levels of PV(49.44±26.83 ml and 51.7±22.2 ml,P=0.021 and 0.043) than BPH patients with normal weight (38.10 ± 10.64 ml).Additionally,BPH patients with abdominal obesity had significantly higher levels of PV than BPH patients without abdominal obesity(50.26±26.51 ml vs.38.99± 11.25ml,P=0.005).BPH patients with low HDL-C had significantly higher PV than BPH patients with normal HDL-C[(54.23±28.92)ml vs.(40.40± 14.87) ml,P=0.009].The values of PV,PSA in the BPH patients with elevated FBS were significantly higher than in BPH patients with normal FBS (t=3.17 and 2.4I,P= 0.035 and 0.013).BPH patients with insuline resistance (IR) had higher values of PV and longer courses of LUTS than BPH patients without IR (t= 3.43 and 3.58,P-0.001).The PV was positively correlated with BMI (r= 0.459.P= O.OOO),FINS (r= 0.42,P=O.OOI),HOMA-IR (r= 0.49,P= 0.003) and gatively correlated with HDL-C (r= 0.38,P-0.000)- Multiple linear stepwise regression analysis showed that PV was closely correlated with HOMA-IR.Conclusions MS has evident effects on the occurrence and development of BPH.