CAJ | 학술논문

目的观察清远市地区产超广谱β-内酰胺酶(ESBLs)大肠埃希菌的耐药性和流行情况,指导临床用药.方法应用MicroScan Auto SCAN-4、专用NC21鉴定板检测180例大肠埃希菌ESBLs的产生和其体外对抗生素的耐药性.结果产ESBLs大肠埃希菌阳性率51.1%,以儿科(100%)最高、重症监护病房(81.8%)次之,对头孢菌素类、氨苄西林、哌拉西林、环丙沙星、妥布霉素、复方新诺明呈多重耐药、耐药率42.4%～91.3%,显著高于非产ESBLs大肠埃希菌(P＜0.05～0.01);对亚胺培南、哌拉西林/三唑巴坦具有高敏感性.结论清远地区具有较高的产ESBLs大肠埃希菌检出率,对于产ESBLs大肠埃希菌应用亚胺培南、哌拉西林/三唑巴坦等含β-内酰胺酶抑制剂的复合抗生素有效.
목적관찰청원시지구산초엄보β-내선알매(ESBLs)대장애희균적내약성화류행정황,지도림상용약.방법응용MicroScan Auto SCAN-4、전용NC21감정판검측180례대장애희균ESBLs적산생화기체외대항생소적내약성.결과산ESBLs대장애희균양성솔51.1%,이인과(100%)최고、중증감호병방(81.8%)차지,대두포균소류、안변서림、고랍서림、배병사성、타포매소、복방신낙명정다중내약、내약솔42.4%～91.3%,현저고우비산ESBLs대장애희균(P＜0.05～0.01);대아알배남、고랍서림/삼서파탄구유고민감성.결론청원지구구유교고적산ESBLs대장애희균검출솔,대우산ESBLs대장애희균응용아알배남、고랍서림/삼서파탄등함β-내선알매억제제적복합항생소유효.