CAJ | 학술논문

芳香烃受体是一种胞质转录因子,参与免疫应答、小分子物质代谢、内分泌稳态及黑素合成等多种生物学过程.近年来研究发现,芳香烃受体能够介导外源性小分子化学物质干扰免疫系统,导致机体产生变态反应和自身免疫反应,其在自身免疫性皮肤病的发生发展中也发挥着作用.概述芳香烃受体的信号通路、免疫功能及其与自身免疫性皮肤病相关性的研究进展,进一步了解自身免疫性皮肤病的发病机制,为疾病的免疫治疗提供新思路.
방향경수체시일충포질전록인자,삼여면역응답、소분자물질대사、내분비은태급흑소합성등다충생물학과정.근년래연구발현,방향경수체능구개도외원성소분자화학물질간우면역계통,도치궤체산생변태반응화자신면역반응,기재자신면역성피부병적발생발전중야발휘착작용.개술방향경수체적신호통로、면역공능급기여자신면역성피부병상관성적연구진전,진일보료해자신면역성피부병적발병궤제,위질병적면역치료제공신사로.
Aryl hydrocarbon receptor,a cytosolic transcription factor,takes part in many biological processes including immune response,endocrine secretion,melanin synthesis and metabolism of low-molecular-weight molecules.Recent research has confirmed that aryl hydrocarbon receptor can interfere with immune system and result in allergic reaction and autoimmune response via interacting with low-molecular-weight chemicals.Also,aryl hydrocarbon receptor plays an important role in the development of autoimmune dermatoses.The authors review aryl hydrocarbon receptor signaling pathway,immunological functions and its association with autoimmune dermatoses,which may help to understand the pathogenesis of autoimmune dermatoses,and offer new ideas for immunotherapy of diseases.