中华麻醉学杂志
中華痳醉學雜誌
중화마취학잡지
CHINESE JOURNAL OF ANESTHESIOLOGY
2011年
7期
822-823
,共2页
酰胺类%比重%麻醉,脊椎%剖宫产术%剂量效应关系,药物
酰胺類%比重%痳醉,脊椎%剖宮產術%劑量效應關繫,藥物
선알류%비중%마취,척추%부궁산술%제량효응관계,약물
Amides%Specific gravity%Anesthesia,spinal%Cesarean section%Dose-response relationship,drug
目的 比较剖宫产术患者不同比重罗哌卡因腰麻的半数有效剂量(ED50).方法 择期脊椎-硬膜外联合麻醉下行剖宫产术的单胎足月初产妇40例,年龄20～40岁,采用随机数字表法,将其随机分为2组(n=20):重比重罗哌卡因组(HR组)和轻比重罗哌卡因组(LR组).经L2.3间隙行蛛网膜下腔穿刺,2组第1例患者局麻药的初始剂量均为9mg,HR组和LR组分别给予0.5％重比重和0.5％轻比重罗哌卡因,根据腰麻是否有效按照序贯法确定下一例患者的剂量,剂量间隔为1mg.采用概率单位法计算不同比重罗哌卡因腰麻的ED50及其95％可信区间(CI).结果 0.5％重比重和0.5％轻比重罗哌卡因腰麻的ED50分别为9.34 mg(95％CI 8.34～10.46 mg)和9.64 mg(95％CI 8.90～10.44 mg),二者ED50比较差异无统计学意义(P＞0.05).结论 剖宫产术患者0.5％重比重和0.5％轻比重罗哌卡因腰麻的ED50分别为9.34和9.64 mg,比重因素对罗哌卡因腰麻效果无影响.
目的 比較剖宮產術患者不同比重囉哌卡因腰痳的半數有效劑量(ED50).方法 擇期脊椎-硬膜外聯閤痳醉下行剖宮產術的單胎足月初產婦40例,年齡20～40歲,採用隨機數字錶法,將其隨機分為2組(n=20):重比重囉哌卡因組(HR組)和輕比重囉哌卡因組(LR組).經L2.3間隙行蛛網膜下腔穿刺,2組第1例患者跼痳藥的初始劑量均為9mg,HR組和LR組分彆給予0.5％重比重和0.5％輕比重囉哌卡因,根據腰痳是否有效按照序貫法確定下一例患者的劑量,劑量間隔為1mg.採用概率單位法計算不同比重囉哌卡因腰痳的ED50及其95％可信區間(CI).結果 0.5％重比重和0.5％輕比重囉哌卡因腰痳的ED50分彆為9.34 mg(95％CI 8.34～10.46 mg)和9.64 mg(95％CI 8.90～10.44 mg),二者ED50比較差異無統計學意義(P＞0.05).結論 剖宮產術患者0.5％重比重和0.5％輕比重囉哌卡因腰痳的ED50分彆為9.34和9.64 mg,比重因素對囉哌卡因腰痳效果無影響.
목적 비교부궁산술환자불동비중라고잡인요마적반수유효제량(ED50).방법 택기척추-경막외연합마취하행부궁산술적단태족월초산부40례,년령20～40세,채용수궤수자표법,장기수궤분위2조(n=20):중비중라고잡인조(HR조)화경비중라고잡인조(LR조).경L2.3간극행주망막하강천자,2조제1례환자국마약적초시제량균위9mg,HR조화LR조분별급여0.5％중비중화0.5％경비중라고잡인,근거요마시부유효안조서관법학정하일례환자적제량,제량간격위1mg.채용개솔단위법계산불동비중라고잡인요마적ED50급기95％가신구간(CI).결과 0.5％중비중화0.5％경비중라고잡인요마적ED50분별위9.34 mg(95％CI 8.34～10.46 mg)화9.64 mg(95％CI 8.90～10.44 mg),이자ED50비교차이무통계학의의(P＞0.05).결론 부궁산술환자0.5％중비중화0.5％경비중라고잡인요마적ED50분별위9.34화9.64 mg,비중인소대라고잡인요마효과무영향.
Objective To determine the median effective dose (ED50) of intrathecal (IT) hyperbaric and hypobaric ropivacaine for elective cesarean section.Methods Forty parturients aged 20-40 yr at full term undergoing elective cesarean section under combined spinal-epidural anesthesia were randomized to receive IT 0.5 ％ hyperbaric (group HR) and hypobaric ropivacaine (group LR) ( n =20 each).The initial dose was 9 mg and the dose was increased/decreased by 1 mg in the next parturient using an up-and-down sequential allocation technique.Analgesia was considered acceptable if adequate analgesia reached T7 or higher in response to pin prick until 20 min after IT ropivacaine and no supplemental epidural analgesic was required during the operation.ED50 and 95％confidence interval (CI) were calculated.Results The ED50 and 95 ％ CI were 9.34 mg (95 ％ CI 8.34-10.46mg) for 0.5％ hyperbaric ropivacaine and 9.64 mg (95％ CI 8.90-10.44 mg) for 0.5％ hypobaric ropivacaine.Conclusion Baricity has no effect on the efficacy of IT ropivacaine for cesarean section.
