中华临床营养杂志
中華臨床營養雜誌
중화림상영양잡지
CHINESE JOURNAL OF CLINICAL NUTRITION
2011年
1期
12-15
,共4页
汪亚玲%祁燕伟%白劲松%郑刚%岳云璇
汪亞玲%祁燕偉%白勁鬆%鄭剛%嶽雲璇
왕아령%기연위%백경송%정강%악운선
肠内营养%获得性免疫缺陷综合征%T淋巴细胞免疫功能
腸內營養%穫得性免疫缺陷綜閤徵%T淋巴細胞免疫功能
장내영양%획득성면역결함종합정%T림파세포면역공능
Enteral nutrition%Acquired immune deficiency syndrome%T lymphocytes immune function
目的 研究肠内营养对获得性免疫缺陷综合征(AIDS)患者T淋巴细胞免疫功能的影响.方法 采用随机数字法将79例AIDS患者随机分为两组:(1)对照组(n=33):仅给予常规治疗;(2)肠内营养(EN)组(n=46):在常规治疗的基础上,每日给予EN.于试验前和试验第30天,分别测定两组患者的CD3、CD4、CD8细胞计数.结果 试验前,两组患者的血糖及血丙氨酸转氨酶、天冬氨酸转氨酶、总蛋白(TP)、白蛋白(ALB)和尿素氮、肌酐、前白蛋白(PA)水平间差异均无统计学意义(P均＞0.05);试验第30天,EN组患者的血TP(P=0.015)、ALB(P=0.007)和PA(P=0.022)水平明显高于对照组.对照组试验前与试验第30天的CD3、CD4、CD8细胞计数间差异均无统计学意义(P均＞0.05),EN组患者试验第30天的CD4细胞计数明显高于试验前(P=0.012).结论 EN支持可改善AIDS患者的营养状况和T淋巴细胞免疫功能.
目的 研究腸內營養對穫得性免疫缺陷綜閤徵(AIDS)患者T淋巴細胞免疫功能的影響.方法 採用隨機數字法將79例AIDS患者隨機分為兩組:(1)對照組(n=33):僅給予常規治療;(2)腸內營養(EN)組(n=46):在常規治療的基礎上,每日給予EN.于試驗前和試驗第30天,分彆測定兩組患者的CD3、CD4、CD8細胞計數.結果 試驗前,兩組患者的血糖及血丙氨痠轉氨酶、天鼕氨痠轉氨酶、總蛋白(TP)、白蛋白(ALB)和尿素氮、肌酐、前白蛋白(PA)水平間差異均無統計學意義(P均＞0.05);試驗第30天,EN組患者的血TP(P=0.015)、ALB(P=0.007)和PA(P=0.022)水平明顯高于對照組.對照組試驗前與試驗第30天的CD3、CD4、CD8細胞計數間差異均無統計學意義(P均＞0.05),EN組患者試驗第30天的CD4細胞計數明顯高于試驗前(P=0.012).結論 EN支持可改善AIDS患者的營養狀況和T淋巴細胞免疫功能.
목적 연구장내영양대획득성면역결함종합정(AIDS)환자T림파세포면역공능적영향.방법 채용수궤수자법장79례AIDS환자수궤분위량조:(1)대조조(n=33):부급여상규치료;(2)장내영양(EN)조(n=46):재상규치료적기출상,매일급여EN.우시험전화시험제30천,분별측정량조환자적CD3、CD4、CD8세포계수.결과 시험전,량조환자적혈당급혈병안산전안매、천동안산전안매、총단백(TP)、백단백(ALB)화뇨소담、기항、전백단백(PA)수평간차이균무통계학의의(P균＞0.05);시험제30천,EN조환자적혈TP(P=0.015)、ALB(P=0.007)화PA(P=0.022)수평명현고우대조조.대조조시험전여시험제30천적CD3、CD4、CD8세포계수간차이균무통계학의의(P균＞0.05),EN조환자시험제30천적CD4세포계수명현고우시험전(P=0.012).결론 EN지지가개선AIDS환자적영양상황화T림파세포면역공능.
Objective To investigate the effect of enteral nutrition (EN) on the T lymphocytes-mediated immune function in patients with acquired immune deficiency syndrome (AIDS). Methods Totally 79 AIDS patients were randomly divided into enteral nutrition ( EN ) group ( supported with EN daily in addition to conventional treatment; n = 46) and control group (underwent conventional treatment only; n = 33 ). T lymphocytes including CD3, CD4, and CD8 cells as well as blood biochemical parameters including alanine aminotransferase ( ALT), aspartate aminotransferase (AST), glucose ( Glu ), total protein (TP), albumin ( ALB ), blood urea nitrogen (BUN) , Cr, and prealbumin (PA) were determined immediately before management (T0) and on the 30th day(T1). Results ALT, AST, Glu, TP, ALB, BUN, Cr, and PA showed no significant differences between these two groups before management ( all P ＞ 0. 05 ). The levels of TP ( P = 0. 015), ALB ( P = 0. 007 ), and PA ( P =0. 022 ) were significantly higher in EN group than those in control group at T1. The cell counts of CD3, CD4, and CD8 were not significantly different at T0, while the cell count of CD4 was significantly higher in EN group than that in control group at T1 ( P ＜ 0. 05 ). Conclusion EN can improve the nutritional status and T lymphocytesmediated immune function in AIDS patients.
