CAJ | 학술논문

目的探讨三维彩色血管能量成像在鉴别诊断乳腺肿瘤良恶性中的应用价值.方法对114例女性患者共121个乳腺实质性肿块进行三维彩色血管能量成像检查(恶性组63个,良性组58个),并对血管血流等参数进行分析,应用受试者工作特征(ROC)曲线比较各项参数的诊断价值.结果与良性组相比,恶性组肿块内血流指数( FI1)、包含肿块周边3 mm组织的血流指数(FI2)及上述两种参数的比值G2 (FI2/FI1)在两组间差异有统计学意义(P均＜0.05).FI2的ROC曲线下面积最大,FI2与G2曲线下面积比较差异无统计学意义(P＞0.05),FI2与FI1曲线下面积比较差异有统计学意义(P＜0.05).以FI2≥27.385作为临界值,诊断乳腺恶性肿瘤的敏感性为88.9％,特异性为81.0％,阳性预测值为83.6％,阴性预测值为87.0％.结论三维彩色能量成像参数FI2诊断乳腺恶性肿瘤的特异性和敏感性较高；FI2的最佳临界点为≥27.385,有助于乳腺良恶性肿瘤的鉴别诊断.
목적 탐토삼유채색혈관능량성상재감별진단유선종류량악성중적응용개치.방법 대114례녀성환자공121개유선실질성종괴진행삼유채색혈관능량성상검사(악성조63개,량성조58개),병대혈관혈류등삼수진행분석,응용수시자공작특정(ROC)곡선비교각항삼수적진단개치.결과 여량성조상비,악성조종괴내혈류지수( FI1)、포함종괴주변3 mm조직적혈류지수(FI2)급상술량충삼수적비치G2 (FI2/FI1)재량조간차이유통계학의의(P균＜0.05).FI2적ROC곡선하면적최대,FI2여G2곡선하면적비교차이무통계학의의(P＞0.05),FI2여FI1곡선하면적비교차이유통계학의의(P＜0.05).이FI2≥27.385작위림계치,진단유선악성종류적민감성위88.9％,특이성위81.0％,양성예측치위83.6％,음성예측치위87.0％.결론 삼유채색능량성상삼수FI2진단유선악성종류적특이성화민감성교고；FI2적최가림계점위≥27.385,유조우유선량악성종류적감별진단.
Objective To evaluate the value of three-dimensional color power angiography(3D-CPA) in the differential diagnosis of benign and malignant breast tumors.Methods 3D-CPA vascular parameters were collected and analyzed in 121 breast solid lesions (63 malignant,58 benign) in the 114 female patients.The diagnostic performances of each parameter were compared by receiver operating characteristic (ROC)cure.Results The parameters of intra-tumor flow index (FI1),flow index of shells with outside thickness of 3mm surrounding the breast tumors(FI2 ) and the ratio of FI2 and FI1 (G2) in malignant group were significantly higher than those in benign group( P ＜0.05,respectively).Analysis of the areas under ROC curve showed that the areas under FI2 curve was the largest.No significant difference( P ＞0.05) was found between the area under FI2 curve and the area under G2 curve.Comparing the area under FI2 curve to that under FI1,there was significant differences ( P ＜ 0.05).Taking FI2 ≥ 27.385 as the critical value,the sensitivity and specificity for the diagnosis of malignant breast tumors were 88.9％ and 81.0％,and the positive and negative predictive values were 83.6％ and 87.0％ respectively.Conclusions The sensitivity and specificity of 3D-CPA parameter FI2 in the diagnosis of malignant breast tumors were higher than others,FI2 with the optimal critical value of ≥27.385 could help to identify malignant from benign breast tumors.