中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2008年
12期
906-910
,共5页
朱新义%崔兆麟%黄祚军%朱伯健%汪宁
硃新義%崔兆麟%黃祚軍%硃伯健%汪寧
주신의%최조린%황조군%주백건%왕저
既往有偿献血人员%获得性免疫缺陷综合征%队列研究%因素分析,统计学
既往有償獻血人員%穫得性免疫缺陷綜閤徵%隊列研究%因素分析,統計學
기왕유상헌혈인원%획득성면역결함종합정%대렬연구%인소분석,통계학
Previous paid blood-donated people%Acquired immunodeficieney syndrome%Cohort studies%Factor analysis,statistical
目的 研究既往有偿献血人群获得性免疫缺陷综合征(acquired immunodeficiency syndrome,AIDS)发病和死亡规律.方法 采用回顾性队列研究方法,对373例既往有偿献血感染人类免疫缺陷病毒(human immunodeficiency virus,HIV)者的发病、死亡规律及其影响因素进行研究.结果 既往有偿献血人群HIV感染率为35.87%(373/1040),AIDS平均潜伏期为8.87年(95%CI:8.76～8.99,Kaplan-Meier法);感染后10年累计发病率为92.23%(344/373),总人时发病率为11.64/100人年;艾滋病患者1年、3年、5年累计生存率分别为94.48%(325/344)、85.76%(295/344)和83.14%(286/344),中位生存时间超过5年;抗病毒治疗天数[(960.29±486.38)d]、感染年龄[(33.39±9.08)岁]和发病年龄[(41.98±8.88)岁]对艾滋病患者生存时间和(或)生存率均有显著性影响(x2=61.355,P=0.000;x2=6.555,P=0.010;x2=3.969,P=0.046).结论 既往有偿献血人群HIV感染者生存时间较长、生存率较高,均显著高于联合国艾滋病规划署(UNAIDS)的研究结果.
目的 研究既往有償獻血人群穫得性免疫缺陷綜閤徵(acquired immunodeficiency syndrome,AIDS)髮病和死亡規律.方法 採用迴顧性隊列研究方法,對373例既往有償獻血感染人類免疫缺陷病毒(human immunodeficiency virus,HIV)者的髮病、死亡規律及其影響因素進行研究.結果 既往有償獻血人群HIV感染率為35.87%(373/1040),AIDS平均潛伏期為8.87年(95%CI:8.76～8.99,Kaplan-Meier法);感染後10年纍計髮病率為92.23%(344/373),總人時髮病率為11.64/100人年;艾滋病患者1年、3年、5年纍計生存率分彆為94.48%(325/344)、85.76%(295/344)和83.14%(286/344),中位生存時間超過5年;抗病毒治療天數[(960.29±486.38)d]、感染年齡[(33.39±9.08)歲]和髮病年齡[(41.98±8.88)歲]對艾滋病患者生存時間和(或)生存率均有顯著性影響(x2=61.355,P=0.000;x2=6.555,P=0.010;x2=3.969,P=0.046).結論 既往有償獻血人群HIV感染者生存時間較長、生存率較高,均顯著高于聯閤國艾滋病規劃署(UNAIDS)的研究結果.
목적 연구기왕유상헌혈인군획득성면역결함종합정(acquired immunodeficiency syndrome,AIDS)발병화사망규률.방법 채용회고성대렬연구방법,대373례기왕유상헌혈감염인류면역결함병독(human immunodeficiency virus,HIV)자적발병、사망규률급기영향인소진행연구.결과 기왕유상헌혈인군HIV감염솔위35.87%(373/1040),AIDS평균잠복기위8.87년(95%CI:8.76～8.99,Kaplan-Meier법);감염후10년루계발병솔위92.23%(344/373),총인시발병솔위11.64/100인년;애자병환자1년、3년、5년루계생존솔분별위94.48%(325/344)、85.76%(295/344)화83.14%(286/344),중위생존시간초과5년;항병독치료천수[(960.29±486.38)d]、감염년령[(33.39±9.08)세]화발병년령[(41.98±8.88)세]대애자병환자생존시간화(혹)생존솔균유현저성영향(x2=61.355,P=0.000;x2=6.555,P=0.010;x2=3.969,P=0.046).결론 기왕유상헌혈인군HIV감염자생존시간교장、생존솔교고,균현저고우연합국애자병규화서(UNAIDS)적연구결과.
Objective To study incidence and death among previous paid blood-donated AIDS sufferers.Methods A retrospective cohort study was adopted to study incidence and death of 373 previous paid blood-donated HIV sufferers and its effect factors.Results Previous paid blood-donated HIV infection was serious and the infection rate in blood-donated crowd was 35.87%(373/1040);the mean incubation period of AIDS was 8.87 years(95%CI:8.76-8.99,Kaplan-Meier method):the cumulative incidence of AIDS(10 years)was 92.23%(344/373),and the incidence of total sufferers was 11.64/100 person-year;the cumulative probability of survival of one-year,three-year,five-year AIDS sufferers was separately 94.48% (325/344),85.76%(295/344)and 83.14%(286/344),median survival time was over 5 years;the anti-virotic treatment days(960.29±486.38),infection age(33.39±9.08)disease age(41.98±8.88)had significant effects on AIDS sufferers' survival time/survival rate(x2=61.355,P=0.000;x2=6.555,P=0.010;x2=3.969,P=0.046).Conclusion The survival time of previous paid blood-donated HIV cases was longer,and their survival rate was hisher,remarkably higher than the UNAIDS'research findings.
