中华物理医学与康复杂志
中華物理醫學與康複雜誌
중화물리의학여강복잡지
CHINESE JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION
2010年
1期
17-21
,共5页
王熠钊%徐江%黄晓琳%许涛%方征宇%徐琦%涂细凯%杨沛沛
王熠釗%徐江%黃曉琳%許濤%方徵宇%徐琦%塗細凱%楊沛沛
왕습쇠%서강%황효림%허도%방정우%서기%도세개%양패패
硬膜外脊髓电刺激%电压%频率%脊髓%脊髓反射%大鼠
硬膜外脊髓電刺激%電壓%頻率%脊髓%脊髓反射%大鼠
경막외척수전자격%전압%빈솔%척수%척수반사%대서
Epidural spinal cord electrical stimulation%Voltage%Frequency%Spinal cord%Spinalcord reflexes
目的 研究正常大鼠麻醉状态下S_1脊髓节段不同电压及频率硬膜外脊髓电刺激(ESCES)所诱发的脊髓反射,探讨ESCES诱发脊髓反射的发生机制及来源.方法 选取成年雌性Sprague-Dawley大鼠10只,麻醉后手术将电极植入S<,1>脊髓节段,予以波宽200μs、电压强度分别为400,600,1200 mV的单脉冲ESCES;1200 mV时,频率分别为50,60,80,100 Hz的ESCES.以同心圆针电极记录大鼠后肢半腱肌肌腹的肌电信号,观察所诱导脊髓反射的特点.结果 能引起大鼠半腱肌反应的阈值为300 mV.3种电压强度的ESCES能诱导出2种潜伏期成分的脊髓反射,较低的400,600 mV电压强度可诱发出长潜伏期成分,潜伏期分别为(5.27±0.36)ms和(5.19±0.67)ms;较高的1200 mV电压强度可诱发出短潜伏期成分,潜伏期为(2.57±0.23)ms.4种较高频刺激均可诱发出脊髓反射,但刺激后期都出现了脊髓反射脱落后不规律出现,部分大鼠出现了较高频刺激后期脊髓反射完全消失.50 Hz频率的ESCES所诱发脊髓反射的潜伏期和波宽分别为(4.46±1.07)ms和(7.33±1.00)ms,与另外3种频率所诱发脊髓反射相比差异有统计学意义(P<0.05).结论 不同电压的ESCES可诱导出不同来源的脊髓反射.长潜伏期成分可能是兴奋脊髓背根传入神经后引起的单突触反射;短潜伏期成分可能是直接兴奋脊髓内的运动神经元或运动纤维后向下传导引起的肌肉兴奋电反应.4种较高频ESCES所诱发的不规律出现的脊髓反射,可能是一种单突触反射.较高频刺激时脊髓反射的小规律出现可能与较高频刺激的抑制作用有关.
目的 研究正常大鼠痳醉狀態下S_1脊髓節段不同電壓及頻率硬膜外脊髓電刺激(ESCES)所誘髮的脊髓反射,探討ESCES誘髮脊髓反射的髮生機製及來源.方法 選取成年雌性Sprague-Dawley大鼠10隻,痳醉後手術將電極植入S<,1>脊髓節段,予以波寬200μs、電壓彊度分彆為400,600,1200 mV的單脈遲ESCES;1200 mV時,頻率分彆為50,60,80,100 Hz的ESCES.以同心圓針電極記錄大鼠後肢半腱肌肌腹的肌電信號,觀察所誘導脊髓反射的特點.結果 能引起大鼠半腱肌反應的閾值為300 mV.3種電壓彊度的ESCES能誘導齣2種潛伏期成分的脊髓反射,較低的400,600 mV電壓彊度可誘髮齣長潛伏期成分,潛伏期分彆為(5.27±0.36)ms和(5.19±0.67)ms;較高的1200 mV電壓彊度可誘髮齣短潛伏期成分,潛伏期為(2.57±0.23)ms.4種較高頻刺激均可誘髮齣脊髓反射,但刺激後期都齣現瞭脊髓反射脫落後不規律齣現,部分大鼠齣現瞭較高頻刺激後期脊髓反射完全消失.50 Hz頻率的ESCES所誘髮脊髓反射的潛伏期和波寬分彆為(4.46±1.07)ms和(7.33±1.00)ms,與另外3種頻率所誘髮脊髓反射相比差異有統計學意義(P<0.05).結論 不同電壓的ESCES可誘導齣不同來源的脊髓反射.長潛伏期成分可能是興奮脊髓揹根傳入神經後引起的單突觸反射;短潛伏期成分可能是直接興奮脊髓內的運動神經元或運動纖維後嚮下傳導引起的肌肉興奮電反應.4種較高頻ESCES所誘髮的不規律齣現的脊髓反射,可能是一種單突觸反射.較高頻刺激時脊髓反射的小規律齣現可能與較高頻刺激的抑製作用有關.
목적 연구정상대서마취상태하S_1척수절단불동전압급빈솔경막외척수전자격(ESCES)소유발적척수반사,탐토ESCES유발척수반사적발생궤제급래원.방법 선취성년자성Sprague-Dawley대서10지,마취후수술장전겁식입S<,1>척수절단,여이파관200μs、전압강도분별위400,600,1200 mV적단맥충ESCES;1200 mV시,빈솔분별위50,60,80,100 Hz적ESCES.이동심원침전겁기록대서후지반건기기복적기전신호,관찰소유도척수반사적특점.결과 능인기대서반건기반응적역치위300 mV.3충전압강도적ESCES능유도출2충잠복기성분적척수반사,교저적400,600 mV전압강도가유발출장잠복기성분,잠복기분별위(5.27±0.36)ms화(5.19±0.67)ms;교고적1200 mV전압강도가유발출단잠복기성분,잠복기위(2.57±0.23)ms.4충교고빈자격균가유발출척수반사,단자격후기도출현료척수반사탈락후불규률출현,부분대서출현료교고빈자격후기척수반사완전소실.50 Hz빈솔적ESCES소유발척수반사적잠복기화파관분별위(4.46±1.07)ms화(7.33±1.00)ms,여령외3충빈솔소유발척수반사상비차이유통계학의의(P<0.05).결론 불동전압적ESCES가유도출불동래원적척수반사.장잠복기성분가능시흥강척수배근전입신경후인기적단돌촉반사;단잠복기성분가능시직접흥강척수내적운동신경원혹운동섬유후향하전도인기적기육흥강전반응.4충교고빈ESCES소유발적불규률출현적척수반사,가능시일충단돌촉반사.교고빈자격시척수반사적소규률출현가능여교고빈자격적억제작용유관.
Objective To investigate the effects of epidural spinal cord electrical stimulation (ESCES) on spinal cord reflexes in normal adult rats, and to find out where and how the spinal cord reflexes are generated. Methods Ten adult female Sprague Dawley rats were anaesthetized and an electrode was placed at the S, spinal cord segment. Single electric pulses with 200 μs pulse width and voltages of 400 mV, 600 mV and 1200 mV were used in the ESCES. 1200 mV voltages with 50 Hz, 60 Hz, 80 Hz, 100 Hz frequency were also tested. EMG signals were re-corded with concentric needle electrodes in the rats' semitendinosus muscles to observe the characteristics of spinal cord reflexes. Results The voltage threshold for generating semitendinosus muscle response was 300 mV. The three ESCES voltages induced 2 kinds of spinal cord reflexes. The 400 mV and 600 mV stimulation induced spinal cord reflexes with short latency (5.27±0.36 ms and 5.19±0.67 ms respectively). The 1200 mV stimulation volt-age induced spinal cord reflexes with long latency (2.57±0.23 ms). Spinal cord reflexes could be generated by 50 Hz, 60 Hz, 80 Hz, and 100 Hz ESCES. At the higher frequencies, spinal cord reflexes declined late in the ex-periments and then appeared irregular. In some of the rats, spinal cord reflexes vanished entirely late in the stimula-tion experiments. The latency and duration of the spinal cord reflexes induced by 50 Hz ESCES were (4.46 ± 1.07) ms and (7.33±1.00)ms respectively. These were significantly different from the latency and duration initia-ted by 60 Hz, 80 Hz or 100 Hz ESCES. Conclusions Different ESCES voltages induce different spinal cord refle-xes generated differently. The long latency reflexes might be monosynaptic responses mediated by dorsal root excite-ment, while the short latency reflexes might be sarcous exciting electric activity mediated by direct excitement of mo-tor neurons or motor fibers. The irregular spinal cord reflexes induced by higher frequency ESCES might be one kind of monosynaptic response. Irregularly appearing spinal cord reflexes induced by higher frequency stimulation might due to the inhibitory effect of higher frequency stimulation.