CAJ | 학술논문

目的探讨葡萄糖-6-磷酸-异构酶(GPI)在类风湿关节炎(RA)患者诊断中的意义.方法用双抗体夹心酶联免疫吸附试验(ELISA)法检测69例类风湿关节炎(RA)患者,29例其他风湿患者、40例健康对照血清中GPI浓度,同时检测RA患者类风湿因子(RF),环瓜氨酸肽(CCP)抗体、血沉等血液指标.结果 RA患者中GPI浓度为2.41±2.27,其他风湿患者为0.18±0.13,健康对照组为0.11±0.05.GPI浓度在类风湿关节炎患者血清中显著高于其他风湿病组和健康对照组(P＜0.05).结论部分RA患者血清GPI浓度显著增高,GPI可以作为临床诊断RA的指标之一,同时可作为病情活动状况的判断依据.
목적 탐토포도당-6-린산-이구매(GPI)재류풍습관절염(RA)환자진단중적의의.방법 용쌍항체협심매련면역흡부시험(ELISA)법검측69례류풍습관절염(RA)환자,29례기타풍습환자、40례건강대조혈청중GPI농도,동시검측RA환자류풍습인자(RF),배과안산태(CCP)항체、혈침등혈액지표.결과 RA환자중GPI농도위2.41±2.27,기타풍습환자위0.18±0.13,건강대조조위0.11±0.05.GPI농도재류풍습관절염환자혈청중현저고우기타풍습병조화건강대조조(P＜0.05).결론 부분RA환자혈청GPI농도현저증고,GPI가이작위림상진단RA적지표지일,동시가작위병정활동상황적판단의거.
Objective To explore the clinical value of glucose-6 phosphate isomeras(GPI)in diagnosis of rheumatoid arthritis(RA).Methods Serum level of GPI was measured with enzyme linked immunosorbent assay(ELISA)in 69 cases of RA(RA group),29 cases of non-RA rheumatic diseases(non-RA group)and 40 cases of healthy controls(healthy control group).Simultaneously,rheumatoid factor(RF),anti-cyelic citrulinated pepetide antibody(anti-CCP)and erythrocyte sedimentation rate (ESR)were measured in RA patients.Results Serum level of GPI was significantly higher in RA group(2.41±2.27)than that in non-RA group(0.18±0.13)and healthy control group(0.11 ±0.05)(P＜0.05).Conclusion Serum level of GPI is significantly increased in some RA patients.Therefore,GPI may be used as a marker for clinical diagnosis and activity of pathogenetic condition of RA.