国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2010年
8期
897-900
,共4页
特异性卵黄抗体%随机双盲安慰剂对照%临床疗效%安全性
特異性卵黃抗體%隨機雙盲安慰劑對照%臨床療效%安全性
특이성란황항체%수궤쌍맹안위제대조%림상료효%안전성
IgY%Randomize-double-blind%Placebo-controlled study%Efficacy%Safety
目的 评价特异性卵黄抗体(IgY)在治疗外阴阴道念珠菌病的临床疗效和安全性.方法 采用随机双肓、安慰剂对照的方法,选择符合人选标准的100例患者随机使用IgY喷剂或安慰剂.结果 两组各46例患者完成观察,两组患者的年龄、病期、症状均匹配.IgY喷剂组症状以及体征改善(t=2.89,P<0.05)、念珠菌清除率(χ~2=23.10,P<0.001)、临床总有效率(χ~2=7.39,P<0.05)显著优于安慰剂组,IgY喷剂组念珠菌清除率、临床总有效率、临床治愈率分别为71.74%、82.61%、21.74%.结论 IgY喷剂有确切的抗阴道念珠菌活性及临床疗效,但由于临床治愈率较低,仍需进一步开发.
目的 評價特異性卵黃抗體(IgY)在治療外陰陰道唸珠菌病的臨床療效和安全性.方法 採用隨機雙肓、安慰劑對照的方法,選擇符閤人選標準的100例患者隨機使用IgY噴劑或安慰劑.結果 兩組各46例患者完成觀察,兩組患者的年齡、病期、癥狀均匹配.IgY噴劑組癥狀以及體徵改善(t=2.89,P<0.05)、唸珠菌清除率(χ~2=23.10,P<0.001)、臨床總有效率(χ~2=7.39,P<0.05)顯著優于安慰劑組,IgY噴劑組唸珠菌清除率、臨床總有效率、臨床治愈率分彆為71.74%、82.61%、21.74%.結論 IgY噴劑有確切的抗陰道唸珠菌活性及臨床療效,但由于臨床治愈率較低,仍需進一步開髮.
목적 평개특이성란황항체(IgY)재치료외음음도념주균병적림상료효화안전성.방법 채용수궤쌍황、안위제대조적방법,선택부합인선표준적100례환자수궤사용IgY분제혹안위제.결과 량조각46례환자완성관찰,량조환자적년령、병기、증상균필배.IgY분제조증상이급체정개선(t=2.89,P<0.05)、념주균청제솔(χ~2=23.10,P<0.001)、림상총유효솔(χ~2=7.39,P<0.05)현저우우안위제조,IgY분제조념주균청제솔、림상총유효솔、림상치유솔분별위71.74%、82.61%、21.74%.결론 IgY분제유학절적항음도념주균활성급림상료효,단유우림상치유솔교저,잉수진일보개발.
Objective To evaluate the efficacy and safety of IgY spray in treatment of vaginal candidiasis.Methods Randomized,double-blind,placebo-controlled study was conducted.A total of100 patients were met inclusion criteria and randomly assigned to receive IgY or placebo.Results 46subjects in each group completed the study.Age,duration and symptoms were not significantly different between the two treatment groups.The improvements of symptoms and signs in IgY group were better than placebo group(t=2.89,P<0.05);Treatment with IgY rrsulted in better clearance rate.of candida and clinical effects as compared with treatment with lacebo(χ~2=23.10, P<0.05; χ~2=7.39,P<0.05 respectively);The clearance rate of candida,the total efficiency rate and the cure rate were71.74%,82.61%,21.74%respectively in IgY treatment group.Conclusion The results showed IgY had definite anti-candidal activity and clinical effect,but the cure rate was too low,it should be worth exploitation.
