CAJ | 학술논문

肌肽是一种广泛存在于组织中的内源性二肽,可通过抗氧自由基、减少晚期糖基化终末产物、抑制生长因子的产生和抑制肾素-血管紧张素系统等作用,降低肾小球毛细血管基底膜增厚和肾小球硬化,被认为是糖尿病肾病的保护因子.肌肽在体内主要通过肌肽酶水解,后者主要由CNDP1及CNDP2两种基因编码.已有多项研究显示肌肽酶基因多态性可能影响肌肽酶的水平和活性,目前相关研究主要集中于CNDP1第2外显子区的(CTG)n.对肌肽及肌肽酶基因多态性分子机制的研究,可能为糖尿病肾病的预防、诊断及治疗提供一条新途径.
기태시일충엄범존재우조직중적내원성이태,가통과항양자유기、감소만기당기화종말산물、억제생장인자적산생화억제신소-혈관긴장소계통등작용,강저신소구모세혈관기저막증후화신소구경화,피인위시당뇨병신병적보호인자.기태재체내주요통과기태매수해,후자주요유CNDP1급CNDP2량충기인편마.이유다항연구현시기태매기인다태성가능영향기태매적수평화활성,목전상관연구주요집중우CNDP1제2외현자구적(CTG)n.대기태급기태매기인다태성분자궤제적연구,가능위당뇨병신병적예방、진단급치료제공일조신도경.
Carnosine is an endogenously synthesized dipeptide commonly present in mammalian tissue,which can inhibit the thickening of glomerular capillary basement membrane and glomerular sclerosis by scavenging free oxygen radical, inhibiting formation of advanced glycation end products and cytokines, and inhibiting the renin-angiotensin system. It is considered as a protective factor for diabetic nephropathy.Carnosine is degraded predominantly by carnosinase which is coded by CNDP1 and CNDP2. Several studies have shown that the carnosinase gene polymorphism may affect the level and activities of carnosinase, and the current researches have focused on the (CTG) n in CNDP1 exon 2. Studying on the molecular biological mechanisms of carnosine and carnosinase may provide a new pathway to prevent, diagnose, and treat diabetic nephropathy.