中华放射学杂志
中華放射學雜誌
중화방사학잡지
Chinese Journal of Radiology
2010年
12期
1290-1293
,共4页
叶晓丹%袁正%叶剑定%李惠民%朱玉兆%张顺民%刘士远%肖湘生
葉曉丹%袁正%葉劍定%李惠民%硃玉兆%張順民%劉士遠%肖湘生
협효단%원정%협검정%리혜민%주옥조%장순민%류사원%초상생
肺肿瘤%体层摄影术,X线计算机%肺纤维化
肺腫瘤%體層攝影術,X線計算機%肺纖維化
폐종류%체층섭영술,X선계산궤%폐섬유화
Lung neoplasms%Tomography,X-ray computed%Pulmonary fibrosis
目的 评价周围型非小细胞肺癌MSCT廓清参数与肿瘤内部纤维化程度的相关性.方法 用16层CT扫描机对肺癌行平扫和增强后20、30、45、60、75、90、120、180、300、540、720、900和1200 s 13个序列扫描,非离子型对比剂以4 ml/s的流率从肘静脉注入,注射量为420 mg I/kg.分别计算20 min的廓清值、廓清率和廓清率线性斜率等参数.用肺癌间质内弹力纤维和胶原纤维双染色法,对肺癌内部纤维化程度进行分级,分析肺癌组织间质内纤维化程度与各参数的相关性.用非参数统计方法Spearman等级相关分析法分析各参数与肺癌间质纤维化程度的相关性.结果 共获得29个肺癌病灶的廓清参数值和间质纤维化分级资料,其中纤维化分级Ⅰ级10个病灶,Ⅱ级14个,Ⅲ级5个,20 min廓清值为12.1(0.32～58.0)HU,20 min廓清率中位数为15.3%(0.3%～39.2%),20 min廓清率线性斜率中位数为0.0152%/s(0.0007%/s～0.0561%/s).相关性分析发现20 min的廓清值(r=-0.402,P＜0.05)、廓清率(r=-0.372,P＜0.05)和廓清率线性斜率(r=-0.459,P＜0.05)与肺癌中纤维化程度有相关性.结论 非小细胞肺癌间质内纤维化程度影响CT对比剂廓清.
目的 評價週圍型非小細胞肺癌MSCT廓清參數與腫瘤內部纖維化程度的相關性.方法 用16層CT掃描機對肺癌行平掃和增彊後20、30、45、60、75、90、120、180、300、540、720、900和1200 s 13箇序列掃描,非離子型對比劑以4 ml/s的流率從肘靜脈註入,註射量為420 mg I/kg.分彆計算20 min的廓清值、廓清率和廓清率線性斜率等參數.用肺癌間質內彈力纖維和膠原纖維雙染色法,對肺癌內部纖維化程度進行分級,分析肺癌組織間質內纖維化程度與各參數的相關性.用非參數統計方法Spearman等級相關分析法分析各參數與肺癌間質纖維化程度的相關性.結果 共穫得29箇肺癌病竈的廓清參數值和間質纖維化分級資料,其中纖維化分級Ⅰ級10箇病竈,Ⅱ級14箇,Ⅲ級5箇,20 min廓清值為12.1(0.32～58.0)HU,20 min廓清率中位數為15.3%(0.3%～39.2%),20 min廓清率線性斜率中位數為0.0152%/s(0.0007%/s～0.0561%/s).相關性分析髮現20 min的廓清值(r=-0.402,P＜0.05)、廓清率(r=-0.372,P＜0.05)和廓清率線性斜率(r=-0.459,P＜0.05)與肺癌中纖維化程度有相關性.結論 非小細胞肺癌間質內纖維化程度影響CT對比劑廓清.
목적 평개주위형비소세포폐암MSCT곽청삼수여종류내부섬유화정도적상관성.방법 용16층CT소묘궤대폐암행평소화증강후20、30、45、60、75、90、120、180、300、540、720、900화1200 s 13개서렬소묘,비리자형대비제이4 ml/s적류솔종주정맥주입,주사량위420 mg I/kg.분별계산20 min적곽청치、곽청솔화곽청솔선성사솔등삼수.용폐암간질내탄력섬유화효원섬유쌍염색법,대폐암내부섬유화정도진행분급,분석폐암조직간질내섬유화정도여각삼수적상관성.용비삼수통계방법Spearman등급상관분석법분석각삼수여폐암간질섬유화정도적상관성.결과 공획득29개폐암병조적곽청삼수치화간질섬유화분급자료,기중섬유화분급Ⅰ급10개병조,Ⅱ급14개,Ⅲ급5개,20 min곽청치위12.1(0.32～58.0)HU,20 min곽청솔중위수위15.3%(0.3%～39.2%),20 min곽청솔선성사솔중위수위0.0152%/s(0.0007%/s～0.0561%/s).상관성분석발현20 min적곽청치(r=-0.402,P＜0.05)、곽청솔(r=-0.372,P＜0.05)화곽청솔선성사솔(r=-0.459,P＜0.05)여폐암중섬유화정도유상관성.결론 비소세포폐암간질내섬유화정도영향CT대비제곽청.
Objective To correlate dynamic parameters at contrast enhanced CT and interstitial fibrosis grade of non-small cell lung cancer (NSCLC). Methods Twenty-nine patients with NSCLC were evaluated by multi-slice CT. Images were obtained before and at 20,30,45,60,75,90,120,180,300,540,720,900 and 1200 s after the injection of contrast media, which was administered at a rate of 4 ml/s for a total of 420 mg I/kg body weight. Washout parameters were calculated. Lung cancer specimens were stained with hematoxylin-eosin stain and collagen and elastica double stain. Spearman test was made to analyze correlation between dynamic parameters and interstitial fibrosis grade of tumor. Results Twentynine NSCLC demonstrated washout at 20 min 12. 1 (0. 32-58.0 ) HU, washout ratio at 20 minutes 15.3% (0. 3%-39.2% ), slope of washout at 20 minutes 0. 0152 %/s ( 0. 0007%/s-0. 0561%/s ).Interstitial fibrosis of 29 lesions was graded as grade Ⅰ (10), grade Ⅱ (14) and grade Ⅲ (5). There were significant correlation between washout at 20 min ( r = - 0. 402, P ＜ 0. 05 ), washout ratio at 20 min ( r =-0.372,P＜0.05), slope of washout ratio (r = -0.459,P ＜0.05) and interstitial fibrosis grade in tumors. Conclusion NSCLC washout features at dynamic multi-detector CT correlates with interstitial fibrosis in the tumor.
