中国医药
中國醫藥
중국의약
CHINA MEDICINE
2009年
4期
258-259
,共2页
肺癌%瘦素%血管内皮生长因子
肺癌%瘦素%血管內皮生長因子
폐암%수소%혈관내피생장인자
Lung cancer%Leptin%Vascular endothelial growth factor
目的 探讨瘦素与血管内皮生长因子在肺腺癌检测中的临床意义.方法 选取64例肺癌患者为肺癌组,30例肺部良性疾病患者为肺良性疾病组及70例健康对照者为对照组,采用放射免疫法测定3组人群的瘦素水平,酶联免疫吸附法测定3组人群的血管内皮生长因子水平,并分析其与肺癌发生的相关性.结果 3组人群血清瘦素和血管内皮生长因子水平分别为肺癌组(8.67±2.28)μg/L和(198.67 4±27.28)μg/L,肺部良性疾病组(6.75±1.95)μg/L和(76.75±20.95)μg/L,健康对照组(5.75 ±1.70)μg/L和(50.75 ±19.70)μg/L,肺癌组与肺部良性疾病组和对照组比较差异均具有统计学意义(均P<0.01),而肺部良性疾病组和对照组比较,差异无统计学意义(P>0.05).3组人群瘦素水平和血管内皮牛长因子水平呈正相关,相关系数分别为0.507,0.463,0.545.结论 血清瘦素和血管内皮生长因子水平升高可能与肺癌发生有关.
目的 探討瘦素與血管內皮生長因子在肺腺癌檢測中的臨床意義.方法 選取64例肺癌患者為肺癌組,30例肺部良性疾病患者為肺良性疾病組及70例健康對照者為對照組,採用放射免疫法測定3組人群的瘦素水平,酶聯免疫吸附法測定3組人群的血管內皮生長因子水平,併分析其與肺癌髮生的相關性.結果 3組人群血清瘦素和血管內皮生長因子水平分彆為肺癌組(8.67±2.28)μg/L和(198.67 4±27.28)μg/L,肺部良性疾病組(6.75±1.95)μg/L和(76.75±20.95)μg/L,健康對照組(5.75 ±1.70)μg/L和(50.75 ±19.70)μg/L,肺癌組與肺部良性疾病組和對照組比較差異均具有統計學意義(均P<0.01),而肺部良性疾病組和對照組比較,差異無統計學意義(P>0.05).3組人群瘦素水平和血管內皮牛長因子水平呈正相關,相關繫數分彆為0.507,0.463,0.545.結論 血清瘦素和血管內皮生長因子水平升高可能與肺癌髮生有關.
목적 탐토수소여혈관내피생장인자재폐선암검측중적림상의의.방법 선취64례폐암환자위폐암조,30례폐부량성질병환자위폐량성질병조급70례건강대조자위대조조,채용방사면역법측정3조인군적수소수평,매련면역흡부법측정3조인군적혈관내피생장인자수평,병분석기여폐암발생적상관성.결과 3조인군혈청수소화혈관내피생장인자수평분별위폐암조(8.67±2.28)μg/L화(198.67 4±27.28)μg/L,폐부량성질병조(6.75±1.95)μg/L화(76.75±20.95)μg/L,건강대조조(5.75 ±1.70)μg/L화(50.75 ±19.70)μg/L,폐암조여폐부량성질병조화대조조비교차이균구유통계학의의(균P<0.01),이폐부량성질병조화대조조비교,차이무통계학의의(P>0.05).3조인군수소수평화혈관내피우장인자수평정정상관,상관계수분별위0.507,0.463,0.545.결론 혈청수소화혈관내피생장인자수평승고가능여폐암발생유관.
Objective To investigate the relationship of serum leptin concentration, vascular endothelial growth factor(VEGF) and lung carcinoma. Methods Blood samples were collected from 64 patients with lung cancer and 30 patients with lung benign disease were selected from the People's hospital of Heze peony district and 70 healthy people were enrolled as a control group. Serum leptin was measured by radioimmunoassay(RIA) and serum VEGF were measured by ELISA. Results The serum leptin concentration and VEGF in lung cancer group were sig-nificantly higher than in the lung benign disease and healthy control. There was no significant difference of the serum leptin between in the lung benign disease and healthy control( P>0.05 ). Conclusion Our results suggests that increased serum leptin levels may be the risk factor for lung cancer.
