中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2011年
10期
1743-1745
,共3页
周明%王远东%凌国辉%程国华%韩国栋%邹青峰%王建%谭小军%杨嵘皓%卢家玲
週明%王遠東%凌國輝%程國華%韓國棟%鄒青峰%王建%譚小軍%楊嶸皓%盧傢玲
주명%왕원동%릉국휘%정국화%한국동%추청봉%왕건%담소군%양영호%로가령
恩度%化疗%用药时序%肺癌
恩度%化療%用藥時序%肺癌
은도%화료%용약시서%폐암
Endostar%Chemotherapy%Treatment sequence%Lung cancer
目的 观察重组人血管内皮抑素(恩度)与化疗联合应用的不同时序对疗效的影响.方法 60只荷A549人肺癌细胞株移植瘤裸鼠随机分为实验组和对照组,实验组分为D1、D3、D5、D7组,给予恩度治疗并分别在恩度治疗第1、3、5、7天进行化疗,比较各组裸鼠移植瘤瘤体积的变化 及抑瘤率.结果 治疗组裸鼠移植瘤生长速度较对照组均明显减慢,并从恩度治疗后第8～40天均显示差异无统计学意义(P＞0.05)；D3、D5、D7组较D1组移植瘤生长速度慢,且在第40天时点出现明显差异(P＜0.05)；D7组移植瘤生长速度最慢,但与D3、D5组比较差异无统计学意义.D1、D3、D5、D7组抑瘤率分别为47.97％、46.78％、46.91％、53.52％.结论 恩度“窗口期”给予化疗疗效优于恩度与化疗同时给药,恩度给药后第7天进行化疗可能是最佳时点.
目的 觀察重組人血管內皮抑素(恩度)與化療聯閤應用的不同時序對療效的影響.方法 60隻荷A549人肺癌細胞株移植瘤裸鼠隨機分為實驗組和對照組,實驗組分為D1、D3、D5、D7組,給予恩度治療併分彆在恩度治療第1、3、5、7天進行化療,比較各組裸鼠移植瘤瘤體積的變化 及抑瘤率.結果 治療組裸鼠移植瘤生長速度較對照組均明顯減慢,併從恩度治療後第8～40天均顯示差異無統計學意義(P＞0.05)；D3、D5、D7組較D1組移植瘤生長速度慢,且在第40天時點齣現明顯差異(P＜0.05)；D7組移植瘤生長速度最慢,但與D3、D5組比較差異無統計學意義.D1、D3、D5、D7組抑瘤率分彆為47.97％、46.78％、46.91％、53.52％.結論 恩度“窗口期”給予化療療效優于恩度與化療同時給藥,恩度給藥後第7天進行化療可能是最佳時點.
목적 관찰중조인혈관내피억소(은도)여화료연합응용적불동시서대료효적영향.방법 60지하A549인폐암세포주이식류라서수궤분위실험조화대조조,실험조분위D1、D3、D5、D7조,급여은도치료병분별재은도치료제1、3、5、7천진행화료,비교각조라서이식류류체적적변화 급억류솔.결과 치료조라서이식류생장속도교대조조균명현감만,병종은도치료후제8～40천균현시차이무통계학의의(P＞0.05)；D3、D5、D7조교D1조이식류생장속도만,차재제40천시점출현명현차이(P＜0.05)；D7조이식류생장속도최만,단여D3、D5조비교차이무통계학의의.D1、D3、D5、D7조억류솔분별위47.97％、46.78％、46.91％、53.52％.결론 은도“창구기”급여화료료효우우은도여화료동시급약,은도급약후제7천진행화료가능시최가시점.
Objective The improvement of endostar combined with chemotherapy at different sequences.Methods 60 tumor-bearing nude mice which transplanted human lung carcinoma cell A549 were randomly divided into experimental group and control group.And experimental group also were divided into D1,D3,D5,D7 groups,which were given chemotherapy after recombinant human endostatin treatment 1,3,5,7 days.The volumetric change and tumor inhibitory rate were compared between the groups after the therapy finished.Results The treatment group' s growth rates were markedly slower than the control group in 8-40 days after endostar treatment (P ＜0.01 ) ; D3,D5,D7 group's were slower,and markedly different from D1 group's in40 days (P ＜0.05) ;D7 group's was the slowest,but with no difference from D3,D5 group's.The tumor inhibition rate of D1,D3,D5,D7 group were 47.97％,46.78％,46.91％,53.52％.Conclusion The effect of chemotherapy given in endostar window phase were more effective than which two were given in the same time.Chemotherapy given at the 7 day after endostar treatment maybe was the best effective.
