CAJ | 학술논문

在三乙胺与四氢呋喃混合溶剂中,邻乙炔基苯酚与(E)-1,2-二碘-3,3-二甲基-1-丁烯在醋酸钯及碘化亚铜的作用下,在氩气保护下,首先在室温下反应15 h,然后在100℃下再反应13 h,一锅法合成2-(3,3-二甲基)丁炔基苯并呋喃,该方法操作简便,反应产率较好,产物结构经由NMR和MS确证.
재삼을알여사경부남혼합용제중,린을결기분분여(E)-1,2-이전-3,3-이갑기-1-정희재작산파급전화아동적작용하,재아기보호하,수선재실온하반응15 h,연후재100℃하재반응13 h,일과법합성2-(3,3-이갑기)정결기분병부남,해방법조작간편,반응산솔교호,산물결구경유NMR화MS학증.
2-(3,3-Dimethylbut-1-ynyl)benzofuran was synthesized by the reaction of 2-ethynylphenol and (E)-1,2-diiodo-3,3-dimethylbut-1-ene in the presence of palladium(Ⅱ)acetate and copper(Ⅰ)iodide as catalyst via an one-pot reaction in triethylamine-tetrahydrofuran media.The mixture was stirred under argon atmosphere at r.t.for 15 h,and then at 100℃ for 13 h to afford.the target compound.The reaction was readily performed with good yield under mild conditions and convenient operations.The structure of the product was characterized by NMR and MS methods.