CAJ | 학술논문

临床上许多骨不连或者延迟愈合往往出现在骨愈合的早期,等到发现已为时已晚.X线片目测骨盐含量变化达成25%才能分辨,因而无法观察极有临床意义的早期变化.本文介绍了骨折愈合理论和骨不连的定义,多细胞基本单位(BMU)和OPG-RANKL-RANK系统在骨重建中的作用;在超声检测、振动响应分析、机械阻抗分析、骨髓腔造影技术、高分辨率CT等方面对骨的研究以及早期诊断骨折不愈合已有相关的报道,但缺乏分子水平上的早期诊断方法研究.
림상상허다골불련혹자연지유합왕왕출현재골유합적조기,등도발현이위시이만.X선편목측골염함량변화체성25%재능분변,인이무법관찰겁유림상의의적조기변화.본문개소료골절유합이론화골불련적정의,다세포기본단위(BMU)화OPG-RANKL-RANK계통재골중건중적작용;재초성검측、진동향응분석、궤계조항분석、골수강조영기술、고분변솔CT등방면대골적연구이급조기진단골절불유합이유상관적보도,단결핍분자수평상적조기진단방법연구.
Many clinical bone nonunion or delayed union often appear in the early stage of bone healing,but they have been always found too lately.Before X-ray films of visual changes indicates salt content inbones reaching 25%,the very early changes ofclinical significance can not be observed.This paper introduces the theory of fracture healing and the definition of bone nonunionand the significance of the basic multicellular unit(BMU)and the OPG-RANKL-RANK system in bone reconstruction.Many technologies such as ultrasonic testing,vibration analysis,mechanical impedance analysis,the bone marrow cavity imaging technologiy,high-resolution CT etc.have been reported in study on the bone,as well as early diagnosis of fracture nonunion.However,the molecular level of early diagnosis is deficiency.