CAJ | 학술논문

目的探讨门冬氨酸钾镁对心脏手术患者术后心律失常的预防和治疗作用.方法采用多中心、随机、平行、对照的方法,在术后(包括术后当天)连续3 d分别给予试验组门冬氨酸钾镁、对照组氯化钾注射液适量静脉滴注,以维持血钾的正常水平.术后连续心电监测,记录患者心律、电解质及肾功能等指标.结果手术当天、术后第1天、术后第2天两组患者的补钾量比较,差异均有统计学意义(P＜0.05);术前、术后试验组患者的血钾水平与对照组比较,差异均无统计学意义(P＞0.05),在术前、术后即刻、术后当晚,试验组患者的血镁水平高于对照组,差异有统计学意义(P＜0.05);术后试验组患者心房纤颤、房性期前收缩、室性期前收缩的发生率均低于对照组,心脏功能也较对照组改善明显.结论手术前后及时给予门冬氨酸钾镁补充钾、镁离子,与单纯补充氯化钾相比,能更有效地维持患者血钾水平、改善心脏功能并显著减少心律失常的发生.
목적 탐토문동안산갑미대심장수술환자술후심률실상적예방화치료작용.방법 채용다중심、수궤、평행、대조적방법,재술후(포괄술후당천)련속3 d분별급여시험조문동안산갑미、대조조록화갑주사액괄량정맥적주,이유지혈갑적정상수평.술후련속심전감측,기록환자심률、전해질급신공능등지표.결과 수술당천、술후제1천、술후제2천량조환자적보갑량비교,차이균유통계학의의(P＜0.05);술전、술후시험조환자적혈갑수평여대조조비교,차이균무통계학의의(P＞0.05),재술전、술후즉각、술후당만,시험조환자적혈미수평고우대조조,차이유통계학의의(P＜0.05);술후시험조환자심방섬전、방성기전수축、실성기전수축적발생솔균저우대조조,심장공능야교대조조개선명현.결론 수술전후급시급여문동안산갑미보충갑、미리자,여단순보충록화갑상비,능경유효지유지환자혈갑수평、개선심장공능병현저감소심률실상적발생.
Objective To Investigate the prevention effects of potassium and magnesium aspartate on arrhythmia after cardiac surgery.Methods A multi-center,randomized,parallel and controlled method was used to give test group an appropriate intravenous infusion of potassium-magnesium aspartate and control group potassium chloride injection to maintain normal level of blood potassium.Postoperative continuous ECG monitoring was conducted and heart rate,electrolytes and renal function were recorded.Results There was significant difference in potassium supplement between 2 groups on surgery day,days 1,2 after operation (P＜0.05),but there was not in blood potassium level (P＞0.05).The level of magnesium ions was higher in test group than in control,the difference was significant (P＜0.05).The incidence of fibrillation,atrial premature contraction,ventricular extrasystole and ventricular fibrillation was lower in test group than in control,and cardiac function improved more significantly.Conclusion Timely supplement of potassium-magnesium aspartate is more effective to maintain blood potassium,improve cardiac function and reduce significantly the incidence of arrhythmias than pure potassium chloride supplement.