中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
31期
26-28
,共3页
氨氯地平%血管紧张素Ⅱ1型受体阻断剂%原发性高血压%胰岛素抵抗%替米沙坦
氨氯地平%血管緊張素Ⅱ1型受體阻斷劑%原髮性高血壓%胰島素牴抗%替米沙坦
안록지평%혈관긴장소Ⅱ1형수체조단제%원발성고혈압%이도소저항%체미사탄
Amlodipine%Angiotensin Ⅱ 1 receptor blocker%Primary hypertension%Insulin resistance%Telmisartan
目的 探讨血管紧张素Ⅱ1型受体阻断剂治疗原发性高血压的临床疗效及其对胰岛素敏感性的影响.方法 选择原发性高血压患者80例作为研究对象,按随机数字表法分为治疗组和对照组,治疗组40例,采用血管紧张素Ⅱ1型受体阻断剂替米沙坦治疗；对照组40例,采用钙离子拮抗剂氨氯地平治疗,疗程均为8周.比较两组的临床疗效和胰岛素敏感性.结果 治疗组总有效率为75.0％( 30/40),对照组总有效率为72.5％( 29/40),两组比较差异无统计学意义(P＞0.05).治疗组和对照组治疗前胰岛素敏感指数(IsI)分别为-4.5±0.8和-4.7±0.7,差异无统计学意义(P＞0.05),治疗组治疗后ISI为-3.2±0.5,对照组治疗后为-4.4±0.6,两组比较差异有统计学意义(P＜0.05).结论 血管紧张素Ⅱ1型受体阻断剂治疗原发性高血压效果明显,同时可增加胰岛素的敏感性.
目的 探討血管緊張素Ⅱ1型受體阻斷劑治療原髮性高血壓的臨床療效及其對胰島素敏感性的影響.方法 選擇原髮性高血壓患者80例作為研究對象,按隨機數字錶法分為治療組和對照組,治療組40例,採用血管緊張素Ⅱ1型受體阻斷劑替米沙坦治療；對照組40例,採用鈣離子拮抗劑氨氯地平治療,療程均為8週.比較兩組的臨床療效和胰島素敏感性.結果 治療組總有效率為75.0％( 30/40),對照組總有效率為72.5％( 29/40),兩組比較差異無統計學意義(P＞0.05).治療組和對照組治療前胰島素敏感指數(IsI)分彆為-4.5±0.8和-4.7±0.7,差異無統計學意義(P＞0.05),治療組治療後ISI為-3.2±0.5,對照組治療後為-4.4±0.6,兩組比較差異有統計學意義(P＜0.05).結論 血管緊張素Ⅱ1型受體阻斷劑治療原髮性高血壓效果明顯,同時可增加胰島素的敏感性.
목적 탐토혈관긴장소Ⅱ1형수체조단제치료원발성고혈압적림상료효급기대이도소민감성적영향.방법 선택원발성고혈압환자80례작위연구대상,안수궤수자표법분위치료조화대조조,치료조40례,채용혈관긴장소Ⅱ1형수체조단제체미사탄치료；대조조40례,채용개리자길항제안록지평치료,료정균위8주.비교량조적림상료효화이도소민감성.결과 치료조총유효솔위75.0％( 30/40),대조조총유효솔위72.5％( 29/40),량조비교차이무통계학의의(P＞0.05).치료조화대조조치료전이도소민감지수(IsI)분별위-4.5±0.8화-4.7±0.7,차이무통계학의의(P＞0.05),치료조치료후ISI위-3.2±0.5,대조조치료후위-4.4±0.6,량조비교차이유통계학의의(P＜0.05).결론 혈관긴장소Ⅱ1형수체조단제치료원발성고혈압효과명현,동시가증가이도소적민감성.
Objective To explore the clinical curative effects of angiotensin Ⅱ 1 receptor blocker in treating primary hypertension and its effects on insulin sensitivity.Methods Eighty primary hypertension patients were divided into the treatment group ( 40 cases,treated with telmisartan ) and the control group (40cases,treated with amlodipine) by random digits table.The treatment period was 8 weeks.After treatment,the clinical curative effect and insulin sensitivity was compared between the two groups.Results In treatment group and control group,the total effective rate was 75.0％(30/40) and 72.5％(29/40),there was no significant difference (P＞ 0.05 ).Before treatment,the insulin sensitivity index ( ISI ) in treatment group and control group was -4.5 ±0.8 and -4.7 ±0.7 (P ＞ 0.05),after treatment,the ISI was -3.2 ±0.5 and -4.4 ±0.6 (P＜0.05).Conclusion The clinical curative effects of angiotensin Ⅱ 1 receptor blocker in treating primary hypertension are obvious,and may improve the insulin sensitivity.
