中华器官移植杂志
中華器官移植雜誌
중화기관이식잡지
CHINESE JOURNAL OF ORGAN TRANSPLANTATION
2012年
9期
523-527
,共5页
明长生%罗鲜樟%宫念樵%曾凡军%张伟杰%陈知水%陈孝平
明長生%囉鮮樟%宮唸樵%曾凡軍%張偉傑%陳知水%陳孝平
명장생%라선장%궁념초%증범군%장위걸%진지수%진효평
糖尿病%胰腺移植%肾移植%排斥反应%长期存活
糖尿病%胰腺移植%腎移植%排斥反應%長期存活
당뇨병%이선이식%신이식%배척반응%장기존활
Diabetes mellitus%Pancreas transplantation%Kidney transplantation%Rejection%Long-term survival
目的 分析53例胰肾联合移植长期存活情况及其影响因素.方法 回顾性分析2000年1月至2009年6月间施行的53例胰肾联合移植受者和移植物长期存活情况,分析受者死亡原因和移植物功能丧失原因.结果 3、5和8年受者存活率分别为90.1％、89.1％和80.0％,3、5和8年移植胰腺存活率分别为84.9％、84.8％和60.0％,3、5和8年移植肾存活率分别为83.0％、82.6％和53.3％.受者死亡原因分别为感染(4例)、移植肾功能丧失(2例)、心血管急症(1例)和脑卒中(1例).移植胰腺功能丧失的主要原因为带功能受者死亡、排斥反应和外科并发症.移植肾功能丧失的主要原因为排斥反应和带功能受者死亡.结论 胰肾联合移植治疗终末期糖尿病肾病远期效果良好,感染、排斥反应和外科并发症是受者死亡和移植物功能丧失的主要原因.
目的 分析53例胰腎聯閤移植長期存活情況及其影響因素.方法 迴顧性分析2000年1月至2009年6月間施行的53例胰腎聯閤移植受者和移植物長期存活情況,分析受者死亡原因和移植物功能喪失原因.結果 3、5和8年受者存活率分彆為90.1％、89.1％和80.0％,3、5和8年移植胰腺存活率分彆為84.9％、84.8％和60.0％,3、5和8年移植腎存活率分彆為83.0％、82.6％和53.3％.受者死亡原因分彆為感染(4例)、移植腎功能喪失(2例)、心血管急癥(1例)和腦卒中(1例).移植胰腺功能喪失的主要原因為帶功能受者死亡、排斥反應和外科併髮癥.移植腎功能喪失的主要原因為排斥反應和帶功能受者死亡.結論 胰腎聯閤移植治療終末期糖尿病腎病遠期效果良好,感染、排斥反應和外科併髮癥是受者死亡和移植物功能喪失的主要原因.
목적 분석53례이신연합이식장기존활정황급기영향인소.방법 회고성분석2000년1월지2009년6월간시행적53례이신연합이식수자화이식물장기존활정황,분석수자사망원인화이식물공능상실원인.결과 3、5화8년수자존활솔분별위90.1％、89.1％화80.0％,3、5화8년이식이선존활솔분별위84.9％、84.8％화60.0％,3、5화8년이식신존활솔분별위83.0％、82.6％화53.3％.수자사망원인분별위감염(4례)、이식신공능상실(2례)、심혈관급증(1례)화뇌졸중(1례).이식이선공능상실적주요원인위대공능수자사망、배척반응화외과병발증.이식신공능상실적주요원인위배척반응화대공능수자사망.결론 이신연합이식치료종말기당뇨병신병원기효과량호,감염、배척반응화외과병발증시수자사망화이식물공능상실적주요원인.
Objective To determine the long-term results after combined pancreas-kidney transplantation at a single-center institution.Methods Fifty-three consecutive patients with insulin-dependent diabetes mellitus and end-stage nephropathy were followed up for more than three years after combined pancreas-kidney transplantation. Immunosuppressive protocol consisted of tacrolimus ( TAC ),mycophenolate mofetil (MMF),and steroids,and antithymocyte globulin or anti-CD25 receptor mAb.The impact of different risk factors was analyzed on long term patient and graft survival.Results The 3-,5- and 8-year survival rate in recipients was 90.1％,89.1 ％ and 80.0％,respectively.The 3-,5- and 8-year survival rate of pancreas grafts was 84.9％,84.8％ and 60.0％,and that of kidney grafts was 83.0％,82.6％ and 53.3％,respectively.Principal causes of death were Infection (n =4),renal failure (n =2),cardiovascular events (n =1 ),and cerebrovascular accident (n =1 ).Graft failure for the pancreas was caused by death with a functioning graft (n =6),rejection (n =2),thrombosis (n =1 ) and pancreatitis (n =1 ).Graft failure for the kidney was due to rejection (n =9),and death with a functioning graft (n =9).Conclusion This series representing the largest experience with long-term follow up in China confirms an excellent long-term survival.Infection,rejection and surgical complication were the major risk factors leading to deaths and graft loss.
