中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2012年
8期
812-814
,共3页
急性脑出血%VEGF%CRP
急性腦齣血%VEGF%CRP
급성뇌출혈%VEGF%CRP
Acute intra-cerebral hemorrhage%Vascular endothelial growth factor%C-reactive protein
目的 检测急性脑出血患者血清中血管内皮生长因子(VEGF)和C-反应蛋白(CRP)的含量并分析其临床意义. 方法 选取广东省高州市中医院脑病科自2008年8月至2011年8月收治的78例急性脑出血患者(轻度39例,中度25例,重度14例)作为研究组,同期体检中心的78例健康体检者作为对照组,分别采用酶联免疫吸附实验(ELISA)法和免疫比浊法检测2组血清中VEGF、CRP的含量并进行比较分析. 结果 研究组患者血清中VEGF和CRP的含量均明显高于对照组,而且重度、中度、轻度急性脑出血患者血清中VEGF和CRP的含量依次减低,差异均有统计学意义(P＜0.05).研究组患者治疗后死亡16例,存活62例,死亡患者血清中VEGF和CRP的含量明显高于生存患者,差异有统计学意义(P＜0.05). 结论 急性脑出血患者血清中VEGF和CRP的含量明显升高,且该两指标可用于辅助判断急性脑出血的病情严重程度与预后.
目的 檢測急性腦齣血患者血清中血管內皮生長因子(VEGF)和C-反應蛋白(CRP)的含量併分析其臨床意義. 方法 選取廣東省高州市中醫院腦病科自2008年8月至2011年8月收治的78例急性腦齣血患者(輕度39例,中度25例,重度14例)作為研究組,同期體檢中心的78例健康體檢者作為對照組,分彆採用酶聯免疫吸附實驗(ELISA)法和免疫比濁法檢測2組血清中VEGF、CRP的含量併進行比較分析. 結果 研究組患者血清中VEGF和CRP的含量均明顯高于對照組,而且重度、中度、輕度急性腦齣血患者血清中VEGF和CRP的含量依次減低,差異均有統計學意義(P＜0.05).研究組患者治療後死亡16例,存活62例,死亡患者血清中VEGF和CRP的含量明顯高于生存患者,差異有統計學意義(P＜0.05). 結論 急性腦齣血患者血清中VEGF和CRP的含量明顯升高,且該兩指標可用于輔助判斷急性腦齣血的病情嚴重程度與預後.
목적 검측급성뇌출혈환자혈청중혈관내피생장인자(VEGF)화C-반응단백(CRP)적함량병분석기림상의의. 방법 선취광동성고주시중의원뇌병과자2008년8월지2011년8월수치적78례급성뇌출혈환자(경도39례,중도25례,중도14례)작위연구조,동기체검중심적78례건강체검자작위대조조,분별채용매련면역흡부실험(ELISA)법화면역비탁법검측2조혈청중VEGF、CRP적함량병진행비교분석. 결과 연구조환자혈청중VEGF화CRP적함량균명현고우대조조,이차중도、중도、경도급성뇌출혈환자혈청중VEGF화CRP적함량의차감저,차이균유통계학의의(P＜0.05).연구조환자치료후사망16례,존활62례,사망환자혈청중VEGF화CRP적함량명현고우생존환자,차이유통계학의의(P＜0.05). 결론 급성뇌출혈환자혈청중VEGF화CRP적함량명현승고,차해량지표가용우보조판단급성뇌출혈적병정엄중정도여예후.
Objective To investigate the serum levels of vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) in patients with acute intra-cerebral hemorrhage and explore their significance. Methods Seventy-eight patients with acute intra-cerebral hemorrhage (the mild,n=39; the moderate,n=25; and the severe,n=14),treated in our hospital from August 2008 to August 2011,were selected in this research, and 78 healthy controls received healthy examination at the same time were also selected.Enzyme-linked immunoassay (ELISA) was used to detect the serum level of VEGF,while immunoturbidimetry was used to detect the serum level of CRP. Results The levels of VEGF and CRP of acute intra-cerebral hemorrhage patients were all significantly higher than those of healthy persons (P＜0.05); VEGF and CRP serum levels in severe, were decreased in turn with significant difference (P＜0.05).And VEGF and CRP serum levels of dead patients (n=16) were also significantly higher than those of survive patients (n=62, P＜0.05). Conclusion VEGF and CRP serum levels of acute intra-cerebral hemorrhage patients are significantly higher than those of healthy persons, and they all have strong positive relationship with the seventy and prognosis of the disease.
