CAJ | 학술논문

动脉粥样硬化(AS)是引起心脑血管疾病的主要原因.然而,AS的发展过程有免疫反应参与.其中,有巨噬性粒细胞为主要效应细胞的天然免疫反应和淋巴细胞为主要效应细胞的获得性免疫方面.快速启动的天然免疫,包括吞噬性细胞、补体和炎细胞因子,都促进AS的形成.另外,获得性免疫相关的T细胞、抗体、免疫调节性细胞因子对于AS病变的活动、进展亦发挥重要的调节作用.本文综述了近几年来,通心络胶囊治疗AS实验研究进展.为临床应用提供参考.
동맥죽양경화(AS)시인기심뇌혈관질병적주요원인.연이,AS적발전과정유면역반응삼여.기중,유거서성립세포위주요효응세포적천연면역반응화림파세포위주요효응세포적획득성면역방면.쾌속계동적천연면역,포괄탄서성세포、보체화염세포인자,도촉진AS적형성.령외,획득성면역상관적T세포、항체、면역조절성세포인자대우AS병변적활동、진전역발휘중요적조절작용.본문종술료근궤년래,통심락효낭치료AS실험연구진전.위림상응용제공삼고.
Atherosclerosis (AS) is a chronic disease that causes artery walls to thicken and become to less elastic. The result can lead to heart attacks, stroke and other serious cardiovascular illnesses, cerebrovascular disease. However, immune mechanisms have been suggested to play a key role in the whole course development of AS. Which are controversy exists regarding the participation of innate immunity involving macrophages and antigen-specific acquired immunity involving lymphocytes. Rapidly mobilized arms of innate immunity, including phagocytic leukocytes, complement, and proinflammatory cytokines, contribute to AS. In addition, adaptive immunity, with its T cells, antibodies, and immunoregulatory cytokines, power-fully modulates disease activity and progression. Now this article summarizes the remarkable results in research advancement of treated effect in ex-periment of AS by using Tongxinluo capsule, its reviewed in recent several years. Which should be provided clinical applied refer to its.