CAJ | 학술논문

目的应用速度向量成像(VVI)技术评价大鼠腹主动脉硬化不同时期管壁运动特征.方法选择健康SD大鼠24只,基础喂养1周后开始高脂喂养.分别于高脂喂养前、高脂喂养第8、12周末测量大鼠腹主动脉内中膜厚度(IMT)、收缩末期血管内径(Ds),血流收缩期峰值流速(Vs)、阻力指数(RI)、搏动指数(PI);应用VVI技术检测动脉管壁的最大峰值运动速度(V_(max))、最大应变(S_(max))及最大应变率 (SR_(max)).结果高脂喂养8周末腹主动脉内膜欠光滑或不光滑,光镜下见少量泡沫细胞,S_(max)、SR_(max)与高脂喂养前比较明显减低(P<0.05).高脂喂养12周末IMT增厚,部分可见粥样硬化斑块形成,动脉IMT、Ds、Vs、RI、PI与高脂喂养前比较差异均有统计学意义(P<0.05);V_(max)、S_(max)、SR_(max)与高脂喂养前、高脂喂养8周末比较均明显减低(P<0.05).结论 VVI技术可定量评价大鼠动脉硬化不同时期血管壁弹性功能的改变.
목적 응용속도향량성상(VVI)기술평개대서복주동맥경화불동시기관벽운동특정.방법 선택건강SD대서24지,기출위양1주후개시고지위양.분별우고지위양전、고지위양제8、12주말측량대서복주동맥내중막후도(IMT)、수축말기혈관내경(Ds),혈류수축기봉치류속(Vs)、조력지수(RI)、박동지수(PI);응용VVI기술검측동맥관벽적최대봉치운동속도(V_(max))、최대응변(S_(max))급최대응변솔 (SR_(max)).결과 고지위양8주말복주동맥내막흠광활혹불광활,광경하견소량포말세포,S_(max)、SR_(max)여고지위양전비교명현감저(P<0.05).고지위양12주말IMT증후,부분가견죽양경화반괴형성,동맥IMT、Ds、Vs、RI、PI여고지위양전비교차이균유통계학의의(P<0.05);V_(max)、S_(max)、SR_(max)여고지위양전、고지위양8주말비교균명현감저(P<0.05).결론 VVI기술가정량평개대서동맥경화불동시기혈관벽탄성공능적개변.
Objective To evaluate the characteristics of abdominal aorta wall motion in different stages of rats atherosclerosis with velocity vector imaging (VVI) technique. Methods Twenty-four healthy SD rats were on high-fat feeding after one week ordinary diet. Abdominal aortic intima-media thickness (IMT), end-systolic blood vessel diameter (Ds), peak systolic velocity (Vs), resistance index (RI), pulsatility index (PI) were measured before and at the end of 8th and 12nd week. Artery wall peak velocity (V_(max)), maximum tangential strain (S_(max)) and the maximum tangential strain rate (SR_(max)) were caculated with VVI. Results Abdominal aortic intima was rough and a small amount of foam cells were found under the light microscope at the end of 8 weeks of high-fat feeding. The values of Smax and SRmax measured at the end of 8th week of high-fat feeding decreased significantly than those of before high-fat feeding (P<0.05). At the end of 12nd week, abdominal aortic intimal was thicker and atherosclerotic plaque appeared somewhere. There were significant differences in artery IMT, Ds, Vs, RI, PI between before and the end of 2nd week of high-fat feeding (P<0.05);the values of V_(max), S_(max), SR_(max) decreased significantly than those of before and at the end of 8th week of high-fat feeding (P<0.05). Conclusion VVI can quantitatively evaluate the vessel wall elasticity in different stage of arteriosclerosis rats.