CAJ | 학술논문

环氧合酶-2(COX-2)在白血病发生发展过程中具有重要作用,而COX-2抑制剂具有一定的抗白血病作用.大量研究已证实,COX-2抑制剂可通过抑制白血病细胞增殖、促进细胞凋亡、影响细胞周期、抑制白血病细胞转移、逆转白血病细胞耐药等来发挥其抗白血病作用.因此,有关COX-2抑制剂抗白血病作用机制的研究将为白血病的预防和治疗寻找新的靶点.
배양합매-2(COX-2)재백혈병발생발전과정중구유중요작용,이COX-2억제제구유일정적항백혈병작용.대량연구이증실,COX-2억제제가통과억제백혈병세포증식、촉진세포조망、영향세포주기、억제백혈병세포전이、역전백혈병세포내약등래발휘기항백혈병작용.인차,유관COX-2억제제항백혈병작용궤제적연구장위백혈병적예방화치료심조신적파점.
Cyclooxygenase-2 (COX-2) plays an important role in the development of leukemia.COX-2 inhibitor plays a certain anti-leukemia role in the process.Many studies show that COX-2 inhibitor plays antileukemia role by inhibiting the proliferation of leukemia cell,promoting apoptosis,affecting cell cycle,inhibiting cell metastasis and reversing cell drug resistance and so on.Therefore,the researches about the anti-leukemia mechanisms of COX-2 inhibitor will provide a new target in clinical prevention and treatment of leukemia.