中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
11期
1191-1193
,共3页
吕金爽%郑广钧%杨景魁%冯震%柴树德
呂金爽%鄭廣鈞%楊景魁%馮震%柴樹德
려금상%정엄균%양경괴%풍진%시수덕
恶性纤维组织细胞瘤%肺转移瘤%125I放射性粒子
噁性纖維組織細胞瘤%肺轉移瘤%125I放射性粒子
악성섬유조직세포류%폐전이류%125I방사성입자
Malignant fibrous histiocytoma%lung metastases%125I radioactive seeds
目的 探讨CT引导下经皮穿刺放射性125I粒子肿瘤内植入治疗恶性纤维组织细胞瘤(MFH)术后肺转移瘤的短期临床效果.方法 选择MFH术后肺转移瘤患者8例,转移病灶28个,行CT引导下经皮穿刺肿瘤内放射性125I粒子植入,处方剂量80 Gy,粒子活度0.7 mCi(2.59×107 Bq).粒子植入术后6个月复查胸部CT,与粒子植入前比较肿瘤变化,按照国际标准判定疗效.结果 接受粒子植入的瘤体平均照射剂量(172.9±39.9)Gy,D100( 77.7±10.2)Gy,D90 (97.2 ±6.8)Gy.有效率为82.1％(23/28),患者术后生存10.0 ～26.0个月,平均(14.6±3.5)个月,中位生存期13.0个月.结论 放射性粒子对MFH肺部转移病灶短期局部效果明显.
目的 探討CT引導下經皮穿刺放射性125I粒子腫瘤內植入治療噁性纖維組織細胞瘤(MFH)術後肺轉移瘤的短期臨床效果.方法 選擇MFH術後肺轉移瘤患者8例,轉移病竈28箇,行CT引導下經皮穿刺腫瘤內放射性125I粒子植入,處方劑量80 Gy,粒子活度0.7 mCi(2.59×107 Bq).粒子植入術後6箇月複查胸部CT,與粒子植入前比較腫瘤變化,按照國際標準判定療效.結果 接受粒子植入的瘤體平均照射劑量(172.9±39.9)Gy,D100( 77.7±10.2)Gy,D90 (97.2 ±6.8)Gy.有效率為82.1％(23/28),患者術後生存10.0 ～26.0箇月,平均(14.6±3.5)箇月,中位生存期13.0箇月.結論 放射性粒子對MFH肺部轉移病竈短期跼部效果明顯.
목적 탐토CT인도하경피천자방사성125I입자종류내식입치료악성섬유조직세포류(MFH)술후폐전이류적단기림상효과.방법 선택MFH술후폐전이류환자8례,전이병조28개,행CT인도하경피천자종류내방사성125I입자식입,처방제량80 Gy,입자활도0.7 mCi(2.59×107 Bq).입자식입술후6개월복사흉부CT,여입자식입전비교종류변화,안조국제표준판정료효.결과 접수입자식입적류체평균조사제량(172.9±39.9)Gy,D100( 77.7±10.2)Gy,D90 (97.2 ±6.8)Gy.유효솔위82.1％(23/28),환자술후생존10.0 ～26.0개월,평균(14.6±3.5)개월,중위생존기13.0개월.결론 방사성입자대MFH폐부전이병조단기국부효과명현.
Objective To investigate the short-term clinical efficacy of CT-guided percutaneous implantation of 125I radioactive seeds in treating the postoperative lung metastases of malignant fibrous histiocytoma(MFH).Methods Eight patients with lung metastases after MFH surgery received CT-guided percutaneous implantation of 125I radioactive seeds.There are 28 metastasis lesions in total.Prescribed dose (PD) was 80 Gy and radioactivity was 0.7 mCi(2.59 × 107 Bq).Six months after implantation,chest CT-scan was performed and the changes were reviewed according to the international standards.Results Average dose received by tumor was ( 172.9 ± 39.9 ) Gy,D100 ( 77.7 ± 10.2 ) Gy and D90 ( 97.2 ± 6.8 ) Gy.The overall response rate was 82.1％.Patients' survival period was 10.0 - 26.0 ( 14.6 ± 3.5 ) months with the median survival time of 13 months.Conclusion In the treatment of postoperative lung metastases of MFH,implantation of 125I radioactive seeds produces a good short-term clinical efficacy.
