中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2012年
6期
472-474
,共3页
孙春明%周长钰%芦雅萍%郑茹瑜
孫春明%週長鈺%蘆雅萍%鄭茹瑜
손춘명%주장옥%호아평%정여유
主动脉瓣%半胱氨酸%冠心病
主動脈瓣%半胱氨痠%冠心病
주동맥판%반광안산%관심병
Aortic valve%Cysteine%Coronary disease
目的 探讨主动脉瓣钙化的相关危险因素及其与冠状动脉(冠脉)病变程度的关系.方法 2010年4月至2011年4月在天津医科大学第二医院行冠脉造影和超声心动图检查患者188例,将其分为主动脉瓣钙化组(AVC) 101例和非主动脉瓣钙化组(NAVC) 87例,记录性别、年龄、身高、体质量和高血压、糖尿病、吸烟史等一般情况,血糖、血脂、同型半胱氨酸水平等相关化验结果,并对上述指标和主动脉钙化间的关系进行分析.结果 AVC组和NAVC组比较,年龄分别为(67.0±9.0)岁和(59.4±6.9)岁(t=6.74,P=0.000)、男性36例(35.6％)和44例(50.6％)(x2=4.26,P=0.039)、高血压72例(71.3％)和50例(57.5％)(x2=3.92,P=0.048)、胆固醇(5.4±1.0) mmol/L和(4.5±1.0)mmol/L(t=5.70,P=0.000)、三酰甘油(2.2±1.1)mmol/L和(1.6±0.8)mmol/L(t=4.04,P=0.000)、同型半胱氨酸(17.6±8.8)μmol/L和(14.9±6.6)μmol/L(t=2.86,P=0.028).单因素分析结果显示,年龄、性别、高血压、胆固醇、三酰甘油与主动脉钙化具有相关性；按是否患冠心病进行分组后,同型半胱氨酸水平差异无统计学意义(t=0.88,P=0.382).进一步Logistic逐步回归,年龄、胆固醇、三酰甘油、同型半胱氨酸水平均为主动脉瓣钙化的独立危险因素,心脏瓣膜钙化与冠脉病变程度相关(x2 =9.48,P=0.024).结论 主动脉瓣钙化的独立危险因素为年龄、胆固醇、三酰甘油、同型半胱氨酸水平；冠脉病变程度重者主动脉瓣钙化发生率高.
目的 探討主動脈瓣鈣化的相關危險因素及其與冠狀動脈(冠脈)病變程度的關繫.方法 2010年4月至2011年4月在天津醫科大學第二醫院行冠脈造影和超聲心動圖檢查患者188例,將其分為主動脈瓣鈣化組(AVC) 101例和非主動脈瓣鈣化組(NAVC) 87例,記錄性彆、年齡、身高、體質量和高血壓、糖尿病、吸煙史等一般情況,血糖、血脂、同型半胱氨痠水平等相關化驗結果,併對上述指標和主動脈鈣化間的關繫進行分析.結果 AVC組和NAVC組比較,年齡分彆為(67.0±9.0)歲和(59.4±6.9)歲(t=6.74,P=0.000)、男性36例(35.6％)和44例(50.6％)(x2=4.26,P=0.039)、高血壓72例(71.3％)和50例(57.5％)(x2=3.92,P=0.048)、膽固醇(5.4±1.0) mmol/L和(4.5±1.0)mmol/L(t=5.70,P=0.000)、三酰甘油(2.2±1.1)mmol/L和(1.6±0.8)mmol/L(t=4.04,P=0.000)、同型半胱氨痠(17.6±8.8)μmol/L和(14.9±6.6)μmol/L(t=2.86,P=0.028).單因素分析結果顯示,年齡、性彆、高血壓、膽固醇、三酰甘油與主動脈鈣化具有相關性；按是否患冠心病進行分組後,同型半胱氨痠水平差異無統計學意義(t=0.88,P=0.382).進一步Logistic逐步迴歸,年齡、膽固醇、三酰甘油、同型半胱氨痠水平均為主動脈瓣鈣化的獨立危險因素,心髒瓣膜鈣化與冠脈病變程度相關(x2 =9.48,P=0.024).結論 主動脈瓣鈣化的獨立危險因素為年齡、膽固醇、三酰甘油、同型半胱氨痠水平；冠脈病變程度重者主動脈瓣鈣化髮生率高.
목적 탐토주동맥판개화적상관위험인소급기여관상동맥(관맥)병변정도적관계.방법 2010년4월지2011년4월재천진의과대학제이의원행관맥조영화초성심동도검사환자188례,장기분위주동맥판개화조(AVC) 101례화비주동맥판개화조(NAVC) 87례,기록성별、년령、신고、체질량화고혈압、당뇨병、흡연사등일반정황,혈당、혈지、동형반광안산수평등상관화험결과,병대상술지표화주동맥개화간적관계진행분석.결과 AVC조화NAVC조비교,년령분별위(67.0±9.0)세화(59.4±6.9)세(t=6.74,P=0.000)、남성36례(35.6％)화44례(50.6％)(x2=4.26,P=0.039)、고혈압72례(71.3％)화50례(57.5％)(x2=3.92,P=0.048)、담고순(5.4±1.0) mmol/L화(4.5±1.0)mmol/L(t=5.70,P=0.000)、삼선감유(2.2±1.1)mmol/L화(1.6±0.8)mmol/L(t=4.04,P=0.000)、동형반광안산(17.6±8.8)μmol/L화(14.9±6.6)μmol/L(t=2.86,P=0.028).단인소분석결과현시,년령、성별、고혈압、담고순、삼선감유여주동맥개화구유상관성；안시부환관심병진행분조후,동형반광안산수평차이무통계학의의(t=0.88,P=0.382).진일보Logistic축보회귀,년령、담고순、삼선감유、동형반광안산수평균위주동맥판개화적독립위험인소,심장판막개화여관맥병변정도상관(x2 =9.48,P=0.024).결론 주동맥판개화적독립위험인소위년령、담고순、삼선감유、동형반광안산수평；관맥병변정도중자주동맥판개화발생솔고.
Objective To analyze the risk factors of aortic valve calcification,and discuss its correlation with coronary artery disease.Methods A total of 188 patients who underwent coronary angiography (CAG) and transthoracic echocardiography (TTE) were divided into two groups:101cases with aortic valve calcification (AVC) and 87 cases without AVC (NAVC).General data such as sex,age,height,weight and hypertension history,results of blood test such as glucose,lipid and homocysteine(HCY)level were recorded.Results In AVC versus NAVC group,age were (67.0±9.0) years vs.(59.4 ± 6.9) years (t =6.74,P =0.000),men were 36 cases (35.6％) vs.44 cases (50.6％) (t=4.26,P=0.039),hypertension patients were 72 cases (71.3％) vs.50 cases (57.5％)(x2=3.92,P=0.048),total cholesterol were (5.4 ± 1.0) mmol/L vs.(4.5 ± 1.0)mmol/L (t =5.70,P=0.000),triglyceride were (2.2 ± 1.1 ) mmol/L vs.( 1.6 ± 0.8) mmol/L (t =4.04,P =0.000),HCY were (17.6±8.8) μmol/L vs.(14.9±6.6) μmol/L (t=2.86,P=0.028),respectively.One-way analysis showed that age,sex,hypertension,total cholesterol,triglyceride had relationship with aortic valve calcification.When we divided the cases into two groups (with and without coronary disease),there is no significant difference in HCY(t=0.88,P=0.382) between the two groups.Logistic regression indicated that age,total cholesterol,triglycerides,HCY were independent risk factors of aortic valve calcification,the incidence of aortic valve calcification was related with the severity of coronary artery lesion (x2 =9.48,P =0.024 ).Conclusions The independent risk factors of aortic valve calcification are age,cholesterol,triglyceride,HCY.Higher incidence of aortic valve calcification may result in greater severity coronary artery lesion.
