CAJ | 학술논문

目的研究RhoC、MMP2蛋白在卵巢上皮性癌中表达及其在卵巢癌转移中的相互关系.方法采用免疫组织化学方法检测10例正常卵巢组织、12例卵巢上皮性良性肿瘤及91例卵巢癌组织中RhoC与MMP2蛋白的表达情况,并与临床特征相比较.结果 RhoC,MMP2蛋白在卵巢良性肿瘤和卵巢正常组织中均无表达;在卵巢上皮性癌中阳性表达率分别为37.3%和68.1%.在组织分化程度上中、低分化的阳性表达率明显高于高分化程度的肿瘤(P＜0.005),在临床分期中Ⅲ-Ⅳ期肿瘤的阳性率明显高于Ⅰ-Ⅱ期(P＜0.005),有转移的RhoC和MMP2蛋白的表达率明显高于无转移的蛋白表达率(P＜0.005),卵巢癌中RhoC阳性表达与MMP2阳性表达呈现出协同作用,表现出一致的正相关性(r=0.492,P＜0.05).结论 RhoC、MMP2蛋白的表达与卵巢癌的细胞分化程度、临床分期及有无转移密切相关,说明在卵巢癌的侵袭与转移中协同发挥着重要作用.
목적 연구RhoC、MMP2단백재란소상피성암중표체급기재란소암전이중적상호관계.방법 채용면역조직화학방법검측10례정상란소조직、12례란소상피성량성종류급91례란소암조직중RhoC여MMP2단백적표체정황,병여림상특정상비교.결과 RhoC,MMP2단백재란소량성종류화란소정상조직중균무표체;재란소상피성암중양성표체솔분별위37.3%화68.1%.재조직분화정도상중、저분화적양성표체솔명현고우고분화정도적종류(P＜0.005),재림상분기중Ⅲ-Ⅳ기종류적양성솔명현고우Ⅰ-Ⅱ기(P＜0.005),유전이적RhoC화MMP2단백적표체솔명현고우무전이적단백표체솔(P＜0.005),란소암중RhoC양성표체여MMP2양성표체정현출협동작용,표현출일치적정상관성(r=0.492,P＜0.05).결론 RhoC、MMP2단백적표체여란소암적세포분화정도、림상분기급유무전이밀절상관,설명재란소암적침습여전이중협동발휘착중요작용.
Objective To study the expression of RhoC and MMP2 in the different epithelial ovarian tissues and the relationship in the transmission of the ovarian cancer.Methods Using immunohistochemical method,we examined the RhoC and MMP2 expression in 91 malignant epithelial ovarian tissues.12 epithelial ovarian benign tumors and 10 normal ovarian tissues.The comparative studies of the RhoC and MMP2 in ovarian cacer and in the positioning were carried out.Results No expression of RhoC and MMP2 was found out in the normal ovarian tissue.RhoC and MMP2 expression rates were 37.3% and 68.1% in epithelial ovarian tumer,respectively.There were significant differences in RhoC and MMP2.The RhoC and MMP2 in the low differentiated were higher than that of midst or well-differentiated(P＜0.005).Compared to the non-transfer case,The positive rate in the transfer case was highter(P＜0.005).For RhoC and MMP2 expression in the elinical stages Ⅲ-Ⅳ,positive rate was significantly highter than that of stages Ⅰ-Ⅱ(P＜0.005).The positive expression of RhoC and MMP2 shows a positive synergy and consistent positive correlation (r=0.492,P＜0.05).Conclusion Both RhoC and MMP2 protein are related to the pathological types,later chinical stage,and the poorer histological grade,which shows that RhoC MMP2 exhibits a positive synergy and consistent positive correlation with the transmission of the ovarian cancer.