国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2010年
1期
9-11
,共3页
mTOR信号转导通路%mTOR抑制剂%肿瘤治疗
mTOR信號轉導通路%mTOR抑製劑%腫瘤治療
mTOR신호전도통로%mTOR억제제%종류치료
mTOR signal pathway%mTOR inhibitor%Cancer therapy
哺乳动物雷帕霉素靶蛋白(mTOR)是PI3K/Akt/mTOR信号通路下游的重要效应蛋白,其底物主要控制与细胞生长和增殖密切相关的蛋白质的合成.mTOR在多种恶性肿瘤中表达异常,是肿瘤靶向治疗的新靶点.临床前研究和Ⅰ、Ⅱ期临床实验表明,以雷帕霉素及其衍生物为代表的mTOR抑制剂和其它传统抗肿瘤药物的联合应用取得了良好的的抗肿瘤效果,为肿瘤的靶向治疗提供了新的方向.
哺乳動物雷帕黴素靶蛋白(mTOR)是PI3K/Akt/mTOR信號通路下遊的重要效應蛋白,其底物主要控製與細胞生長和增殖密切相關的蛋白質的閤成.mTOR在多種噁性腫瘤中錶達異常,是腫瘤靶嚮治療的新靶點.臨床前研究和Ⅰ、Ⅱ期臨床實驗錶明,以雷帕黴素及其衍生物為代錶的mTOR抑製劑和其它傳統抗腫瘤藥物的聯閤應用取得瞭良好的的抗腫瘤效果,為腫瘤的靶嚮治療提供瞭新的方嚮.
포유동물뢰파매소파단백(mTOR)시PI3K/Akt/mTOR신호통로하유적중요효응단백,기저물주요공제여세포생장화증식밀절상관적단백질적합성.mTOR재다충악성종류중표체이상,시종류파향치료적신파점.림상전연구화Ⅰ、Ⅱ기림상실험표명,이뢰파매소급기연생물위대표적mTOR억제제화기타전통항종류약물적연합응용취득료량호적적항종류효과,위종류적파향치료제공료신적방향.
The mammalian target of rapamycin ( mTOR) is an important effector of the PDK/Akt/ MTOR pathway, which is centrally involved in growth regulation, proliferation control, and cancer cell metabolism. Over-expressions of mTOR can be found in many malignancies, which make mTOR a potential target for cancer therapy. The mTOR inhibitors (rapamycin and its analogues) in combination with traditional anti-tumor drugs have shown reasonable effect in cancer treatment both in pre-clinical experiments and in some stage Ⅰ and Ⅱ clinical trials. The studies provide a new aspect for the targeted treatment of tumors.
