国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2011年
18期
2226-2230
,共5页
彭敏%邓凯贤%王夷黎%周东华%秦艳%刘晓燕
彭敏%鄧凱賢%王夷黎%週東華%秦豔%劉曉燕
팽민%산개현%왕이려%주동화%진염%류효연
宫颈腺癌%hTERC基因%荧光原位杂交技术%高危型HPV感染
宮頸腺癌%hTERC基因%熒光原位雜交技術%高危型HPV感染
궁경선암%hTERC기인%형광원위잡교기술%고위형HPV감염
Cervical adenocarcinomas%hTERC gene%Fluorescence in situ hybridization%High risk of human papillomavirus infection
目的 检测人类染色体端粒酶基因(hTERC)在宫颈腺癌组织中的表达情况,并进一步探讨hTERC基因在宫颈腺癌中异常扩增的临床意义。方法 回顾性分析2000-2010年我院收治的15例宫颈腺癌患者的临床资料。应用荧光原位杂交技术(FISH)检测15例患者存档的病理石蜡切片标本中hTERC基因的扩增情况。同时取15例慢性宫颈炎组织作为正常对照,FISH检测其病理石蜡切片标本中hTERC基因的扩增情况。结果 15例腺癌患者中有4例高危HPV病毒检测阴性。FISH检测15例宫颈腺癌的石蜡标本中的3号染色体hTERC基因15例均呈阳性表达,异常扩增阳性率为100%。宫颈炎对照组中未检测到hTERC基因异常扩增,异常扩增阳性率为0%。两组hTERC基因异常扩增阳性率相比差异有极显著性(P<0.01)。结论 hTERC基因在宫颈腺癌组织中异常扩增,应用FISH技术检测宫颈腺癌中hTERC基因的表达,有助于临床早期诊断宫颈腺癌。
目的 檢測人類染色體耑粒酶基因(hTERC)在宮頸腺癌組織中的錶達情況,併進一步探討hTERC基因在宮頸腺癌中異常擴增的臨床意義。方法 迴顧性分析2000-2010年我院收治的15例宮頸腺癌患者的臨床資料。應用熒光原位雜交技術(FISH)檢測15例患者存檔的病理石蠟切片標本中hTERC基因的擴增情況。同時取15例慢性宮頸炎組織作為正常對照,FISH檢測其病理石蠟切片標本中hTERC基因的擴增情況。結果 15例腺癌患者中有4例高危HPV病毒檢測陰性。FISH檢測15例宮頸腺癌的石蠟標本中的3號染色體hTERC基因15例均呈暘性錶達,異常擴增暘性率為100%。宮頸炎對照組中未檢測到hTERC基因異常擴增,異常擴增暘性率為0%。兩組hTERC基因異常擴增暘性率相比差異有極顯著性(P<0.01)。結論 hTERC基因在宮頸腺癌組織中異常擴增,應用FISH技術檢測宮頸腺癌中hTERC基因的錶達,有助于臨床早期診斷宮頸腺癌。
목적 검측인류염색체단립매기인(hTERC)재궁경선암조직중적표체정황,병진일보탐토hTERC기인재궁경선암중이상확증적림상의의。방법 회고성분석2000-2010년아원수치적15례궁경선암환자적림상자료。응용형광원위잡교기술(FISH)검측15례환자존당적병리석사절편표본중hTERC기인적확증정황。동시취15례만성궁경염조직작위정상대조,FISH검측기병리석사절편표본중hTERC기인적확증정황。결과 15례선암환자중유4례고위HPV병독검측음성。FISH검측15례궁경선암적석사표본중적3호염색체hTERC기인15례균정양성표체,이상확증양성솔위100%。궁경염대조조중미검측도hTERC기인이상확증,이상확증양성솔위0%。량조hTERC기인이상확증양성솔상비차이유겁현저성(P<0.01)。결론 hTERC기인재궁경선암조직중이상확증,응용FISH기술검측궁경선암중hTERC기인적표체,유조우림상조기진단궁경선암。
Objective To detect the expression and clinical significance of amplification of the human telomerase component(hTERC) in the specimens of cervical adenocarcinomas and discuss the clinical significance of its normal amplification. Methods Retrospective analysis was carried out to the clinical material of 15 cervical adenocarcinomaspatients who received operation in our hospital from 2000 to 2010. Their paraffin-embedded cervical tissues were established as experimental group,15 cervical specimens of chronic cervicitis women were established as control group. All of specimens were detected by FISH to evaluate the hTERC gene amplification. Results No control group samples revealed copy number increases of 3q, while 100 % of cervical adenocarcinomas tissues showed extra copies of 3q. hTERC copy numbers in cervical adenocarcinomas were significantly higber than those in control group 1 samples, (P<0.001).Conclusions hTERC gene showed abnormal amplification in the cervical adenocarcinomas. And the detection of hTERC gene amplification by FISH could help the early diagnosis of cervical adenocarcinomas.