CAJ | 학술논문

目的研究甲磺酸多沙唑嗪控释片对良性前列腺增生(BPH)患者下尿路症状(LUTS)及性功能的影响.方法 101例典型的伴有LUTS的BPH患者治疗前进行国际前列腺症状评分(IPSS)、勃起功能障碍国际问卷5(IIEF2-5)调查,给甲磺酸多沙唑嗪控释片4 mg,1次/d,疗程8周.分析治疗后LUTS及性功能改善情况.结果治疗前IPSS评分(19.9±6.5)分,治疗后(14.3±4.0)分(t=7.534,P＜0.001);治疗前IIEF-5评分(9.5±8.5)分,治疗后(14.9±8.8)分(t=5.335,P＜0.001),治疗后各项指标较治疗前有明显改善.IPSS和IIEF2-5呈负相关(r=-0.33,P＜0.001).结论 LUTS是性功能障碍的危险因素,LUTS的严重程度与性功能障碍的发展密切相关.甲磺酸多沙唑嗪控释片在改善LUTS的同时可明显改善患者的性功能状况.
목적 연구갑광산다사서진공석편대량성전렬선증생(BPH)환자하뇨로증상(LUTS)급성공능적영향.방법 101례전형적반유LUTS적BPH환자치료전진행국제전렬선증상평분(IPSS)、발기공능장애국제문권5(IIEF2-5)조사,급갑광산다사서진공석편4 mg,1차/d,료정8주.분석치료후LUTS급성공능개선정황.결과 치료전IPSS평분(19.9±6.5)분,치료후(14.3±4.0)분(t=7.534,P＜0.001);치료전IIEF-5평분(9.5±8.5)분,치료후(14.9±8.8)분(t=5.335,P＜0.001),치료후각항지표교치료전유명현개선.IPSS화IIEF2-5정부상관(r=-0.33,P＜0.001).결론 LUTS시성공능장애적위험인소,LUTS적엄중정도여성공능장애적발전밀절상관.갑광산다사서진공석편재개선LUTS적동시가명현개선환자적성공능상황.
Objective To study the therapeutic effect of cardura on lower urinary tract symptoms (LUTS) and ejectile dystunction(ED) in men with benign prostatic hyperplasia (BPH).Methods One hundred and one cases with BPH and typical LUTS were investigated using the International Prostate Symptom Score (IPSS) and International Index of Erectile Function 5 (IIEF-5)before and after treatment. The patients were given cardura 4 mg, once a day for 8 weeks. The LUTS and ED were was analyzed after treatment. Results The IPSS was scores ( 14.3 ± 4.0) after treatment, and it was lower than before (mean scores: 19.9±6.5, t= 7.534, P＜0.001). The IIEF2-5 was(14.9±8.8)scores after treatment, and it was higher than before (mean scores: 9.5±8. 5, t = 5. 335, P＜ 0. 001 ), respectively. There was statistically significant correlation between IIEF2-5 and IPSS score (r= -0. 327, P＜0. 001 ). Various indexes were significantly improved after cardura treatment as compared with pretreatment (P＜0.001). Conclusions LUTS is dangerous factor for sexual dysdysfunction, and the severity of LUTS is closely related to the development of sexual dysfunction. Cardura can at once improve the sexual function and LUTS of BPH patients.