CAJ | 학술논문

目的探讨白细胞介素(IL)-23R基因单核苷酸多态性rs1343151与强直性脊柱炎(AS)的关系.方法常规方法对104例As患者和95名健康人群外周血进行基因组DNA抽提,用TaqMan探针对rs1343151位点进行聚合酶链反应(PCR)分型.应用x2检验统计分析病例组和对照组等位基因频率、等位基因型频率及其患病风险.结果 rs1343151位点各基凶型频率在AS组中分别为90.4%(C/C)、9.6%(C/T),在对照组中分别为91.6%(C/C)、8.4%(C/T),2组之间的基因型频率分布差异无统计学意义(x2=0.086,P>0.05);2组C和T等位基凶频率差异无统计学意义(x2=0.082,P>0.05).结论 IL-23R单核苷酸多态性rs1343151不是影响中国人群AS患者致病的主要因素.
목적 탐토백세포개소(IL)-23R기인단핵감산다태성rs1343151여강직성척주염(AS)적관계.방법 상규방법대104례As환자화95명건강인군외주혈진행기인조DNA추제,용TaqMan탐침대rs1343151위점진행취합매련반응(PCR)분형.응용x2검험통계분석병례조화대조조등위기인빈솔、등위기인형빈솔급기환병풍험.결과 rs1343151위점각기흉형빈솔재AS조중분별위90.4%(C/C)、9.6%(C/T),재대조조중분별위91.6%(C/C)、8.4%(C/T),2조지간적기인형빈솔분포차이무통계학의의(x2=0.086,P>0.05);2조C화T등위기흉빈솔차이무통계학의의(x2=0.082,P>0.05).결론 IL-23R단핵감산다태성rs1343151불시영향중국인군AS환자치병적주요인소.
Objective To investigate the association between interleukin-23 receptor (IL-23R) gene rs1343151 single nucleotide polymorphism and ankylosing spondylitis (AS) in Chinese Han patients. Methods The genotypes of IL-23R SNP was detected in 104 Chinese AS patients and 95 ethnically matched blood donors by TaqMan probe assays. The allele and genotype frequencies and risk factors of AS were analyzed by Chi-square test in both groups. Results The rs 1343151 genotypes in AS patients consisted of homozygote C/C (90.4%),C/T (9.6%), while The rs1343151 genotypes in the controls were. composed of C/C (91.6%), C/T (8.4%). No significant difference was found in the distribution of rs1343151 genotypes between these two groups (x2=0.086, P>0.05). The frequency of rs1343151 allele in AS patients was also not significantly increased when compared with the control group (x2 =0.082,P>0.05). Conclusion There may be no association between the IL-23R gene rs1343151 SNP and ankylosing spondylitis in Chinese Hart population.