CAJ | 학술논문

目的探讨胰岛素样生长因子(IGF)-1及胰岛素样生长因子结合蛋白(IGFBP)-3在过敏性紫癜(HSP)中的作用.方法采用放射免疫法方法测定45例HSP患儿不同时期的血清IGF-1及IGFBP-3、C反应蛋白(CRP)水平.采用t检验和直线相关关系.结果 HSP急性发作组血清IGF-1[(452±183)μg/L]、IGFBP-3[(13 897±3124)μg/L]及CRP[(20±8)mg/L]水平升高,与健康对照组和缓解组比较,差异均有统计学意义(t值分别为3.42、4.10、11.17、11.63、8.59、9.86.P均<0.01);HSP缓解组血清IGF-1、IGFBP-3及CRP与健康对照组比较,差异无统计学意义(t=0.3,4、0.34、0.52,P均>0.05).HSP急性期并发肾损害组血清IGF-1[(621±253)μg/L]、IGFBP-3[(18 763±3173)μg/L]水平升高,与无肾损害组比较,差异有统计学意义(t值分别为4.21、7.26,P均<0.01),有胃肠道症组血清IGF-1[(479±192)μg/L]、IGFBP-3[(13 986±3162)μg/L]水平与无胃肠道症状组比较,差异无统计学意义(t值分别为0.83、0.16,P均>0.05);血清CRP水平在肾损害组与非肾损害组及胃肠道症组与无胃肠道症状组问差异均无统计学意义(t值分别为0.56、0.32.P均>0.05).HSP急性期患儿血IGF-1、IGFBP-3与CRP浓度之间呈直线正相关(r值分别为0.624,0.672,JP均<0.01).结论 IGF-1、IGFBP-3参与了HSP疾病的病理生理过程,血清IGF-1、IGFBP-3测定对紫癜性肾损害的诊断、病情监测及预后判断有一定帮助.
목적 탐토이도소양생장인자(IGF)-1급이도소양생장인자결합단백(IGFBP)-3재과민성자전(HSP)중적작용.방법 채용방사면역법방법측정45례HSP환인불동시기적혈청IGF-1급IGFBP-3、C반응단백(CRP)수평.채용t검험화직선상관관계.결과 HSP급성발작조혈청IGF-1[(452±183)μg/L]、IGFBP-3[(13 897±3124)μg/L]급CRP[(20±8)mg/L]수평승고,여건강대조조화완해조비교,차이균유통계학의의(t치분별위3.42、4.10、11.17、11.63、8.59、9.86.P균<0.01);HSP완해조혈청IGF-1、IGFBP-3급CRP여건강대조조비교,차이무통계학의의(t=0.3,4、0.34、0.52,P균>0.05).HSP급성기병발신손해조혈청IGF-1[(621±253)μg/L]、IGFBP-3[(18 763±3173)μg/L]수평승고,여무신손해조비교,차이유통계학의의(t치분별위4.21、7.26,P균<0.01),유위장도증조혈청IGF-1[(479±192)μg/L]、IGFBP-3[(13 986±3162)μg/L]수평여무위장도증상조비교,차이무통계학의의(t치분별위0.83、0.16,P균>0.05);혈청CRP수평재신손해조여비신손해조급위장도증조여무위장도증상조문차이균무통계학의의(t치분별위0.56、0.32.P균>0.05).HSP급성기환인혈IGF-1、IGFBP-3여CRP농도지간정직선정상관(r치분별위0.624,0.672,JP균<0.01).결론 IGF-1、IGFBP-3삼여료HSP질병적병리생리과정,혈청IGF-1、IGFBP-3측정대자전성신손해적진단、병정감측급예후판단유일정방조.
Objecfive To investigate the role of serum Insulin-like growth factor(IGF)-1,insulinlike growth factor-binding potein(IGFBP)-3 in children with Henoch-Schonlein purpura(HSP).Methods The serum concentration of IGF-1,1GFBP-3 was measured by enzyme-linked immunosorbent assay(ELISA)method in 45 acute SHP patients,40 recoverv patients and 30 healthy controls.Results The serum levels of IGF-1 [(452±183)μg/L],IGFBP-3 [(13 897±3124)μg/L] and C-reactive protein(CRP)[(20±8)mg/L]in acute phase were significantly higher than those in healthy controls(P<0.0 1)and higher than those during recovery period.The serum level of IGF-1,IGFBP-3 for the HSP patients dropped back slowly and their levels during recovery period were the same as those in healthy controls(P>0.05).The serum levels of IGF-1[(621±253)μg/L] and IGFBP-3[(18 763±3173)μg/L] were higher in the renal damage group than in the non-renal damage group(P<0.01).and the same in patients with gastrointestinal symptoms group as in patients without gastrointestinal symptoms group(P>0.05).whereas the serum level of CRP was not significantly different(P>0.05).The serum levels of IGF-1,IGFBP-3 showed positive correlation with the level of CRP(r=0.624,0.672,P<0.01).Conclusion The IGF-1 and IGFBP-3 may play an important role in the pathological mechanism of HSP.The level of IGF-1 may be used as an indicator for HSP disease activity and progression.IGF-1 mav have a close relation with the damage"of renaJ system in HSP.