CAJ | 학술논문

甲状腺激素在机体的牛理及代谢过程巾发挥重要作用.作为评价甲状腺功能的敏感指标,血清促甲状腺素(TSH)浓度在个体之间差异明显并且主要由遗传因素所决定.在经历了传统的连锁分析及候选基因关联分析之后,全基因组关联分析(GWAS)在研究血清TSH易感基因过程中取得了重大进展,并发现了许多新的易感位点.本文主要综述与血清TSH水平相关的基因,并对这些研究的未来进行了展望.
갑상선격소재궤체적우리급대사과정건발휘중요작용.작위평개갑상선공능적민감지표,혈청촉갑상선소(TSH)농도재개체지간차이명현병차주요유유전인소소결정.재경력료전통적련쇄분석급후선기인관련분석지후,전기인조관련분석(GWAS)재연구혈청TSH역감기인과정중취득료중대진전,병발현료허다신적역감위점.본문주요종술여혈청TSH수평상관적기인,병대저사연구적미래진행료전망.
Thyroid hormones play major roles in the regulation of a wide range of metabolie and physiologic processes.Serum thyroid-stimulating hormone( TSH ) concentration,a sensitive barometer of thyroid function,shows significant individual difference in which genetic variation is a major factor.After using traditional genetic linkage studies and candidate gene association studies to explore the suseeptibility genes of serum TSH,many progresses have been made and new susceptibility genes have been identified by genome-wide association study (GWAS).In this review,we focus on the susceptibility genes of serum TSH levels and also the future prospect that may be obtained from these studies.