CAJ | 학술논문

目的:观察充血性心力衰竭(CHF)病人血清血管细胞粘附分子-1(VCAM-1)、细胞间粘附分子-1(ICAM-1)浓度变化.方法:应用酶联免疫吸附分析法测定56例充血性心力衰竭病人和25名健康对照者血清VCAM-1及ICAM-1.结果:病人血清ICAM-1浓度为(355±45)ng/ml,健康对照组血清ICAM-1浓度为(220±36)ng/ml(P＜0.05).CHF病人血清VCAM-1浓度为(655±75)ng/ml,健康对照组血清VCAM-1浓度为(420±46) ng/ml(P＜0.05).心功能Ⅳ级病人血清VCAM-1浓度为(755±78)ng/ml,高于心功能Ⅱ级、Ⅲ级病人血清VCAM-1浓度(612±47)ng/ml(P＜0.05).冠心病CHF病人血清ICAM-1与VCAM-1浓度分别为(375±47)ng/ml和(650±65)ng/ml,扩张性心肌病CHF病人血清ICAM-1与VCAM-1浓度分别为(375±47)ng/ml和(665±55)ng/ml,两组相比P＞0.05.结论:CHF病人血清VCAM-1及ICAM-1浓度升高,而且VCAM-1浓度和心力衰竭的程度呈正相关;VCAM-1及ICAM-1浓度升高和心力衰竭病因无关,提示炎症有可能是充血性心力衰竭发病机制之一.
목적:관찰충혈성심력쇠갈(CHF)병인혈청혈관세포점부분자-1(VCAM-1)、세포간점부분자-1(ICAM-1)농도변화.방법:응용매련면역흡부분석법측정56례충혈성심력쇠갈병인화25명건강대조자혈청VCAM-1급ICAM-1.결과:병인혈청ICAM-1농도위(355±45)ng/ml,건강대조조혈청ICAM-1농도위(220±36)ng/ml(P＜0.05).CHF병인혈청VCAM-1농도위(655±75)ng/ml,건강대조조혈청VCAM-1농도위(420±46) ng/ml(P＜0.05).심공능Ⅳ급병인혈청VCAM-1농도위(755±78)ng/ml,고우심공능Ⅱ급、Ⅲ급병인혈청VCAM-1농도(612±47)ng/ml(P＜0.05).관심병CHF병인혈청ICAM-1여VCAM-1농도분별위(375±47)ng/ml화(650±65)ng/ml,확장성심기병CHF병인혈청ICAM-1여VCAM-1농도분별위(375±47)ng/ml화(665±55)ng/ml,량조상비P＞0.05.결론:CHF병인혈청VCAM-1급ICAM-1농도승고,이차VCAM-1농도화심력쇠갈적정도정정상관;VCAM-1급ICAM-1농도승고화심력쇠갈병인무관,제시염증유가능시충혈성심력쇠갈발병궤제지일.