中华核医学杂志
中華覈醫學雜誌
중화핵의학잡지
CHINESE JOURNAL OF NUCLEAR MEDICINE
2008年
4期
251-252
,共2页
骨肿瘤%肿瘤转移%放射性核素显像%HL91
骨腫瘤%腫瘤轉移%放射性覈素顯像%HL91
골종류%종류전이%방사성핵소현상%HL91
Bone neoplasms%Neoplasm metastasis%Radionuclide imaging%HL91
目的 探讨乏氧显像剂99Tcm-4,9-二氮-3,3,10,10-四甲基十二烷-2,11-二酮肟(HL91)在骨转移瘤诊断中的应用价值.方法 27例骨痛患者,其中19例经病理检查证实为骨转移瘤(未行放化治疗),8例为骨良性病变.所有患者均行99Tcm-亚甲基二膦酸盐(MDP)显像,2 d后注射99Tcm-HL91740 MBq,注射4 h后依据99Tcm-MDP显示的病灶进行断层显像,利用感兴趣区(ROI)技术,计算肿瘤与对侧正常组织的放射性(T/N)比值.采用SPSS 11.0软件进行t检验.结果 19例骨转移患者99Tcm-MDP显像提示的85处病灶,有79处99Tcm-HL91显像呈异常放射性浓聚;经病理检查或临床证实的8例骨良性疾病中,99Tcm-MDP显像提示的12处病灶99Tcm-HL91显像全部呈阴性.HL91断层显像骨转移组和骨良性疾病组的T/N比值分别为1.877±0.288和0.735±0.236,差异有统计学意义(t=13.065,P＜0.05).肺癌、前列腺癌骨转移病灶的T/N比值分别为1.915±0.344和1.825±0.175,2种病理类型间差异无统计学意义(t=1.378,P＞0.05).结论 99Tcm-HL91显像在骨骼良恶性病变的鉴别中可能有一定价值.
目的 探討乏氧顯像劑99Tcm-4,9-二氮-3,3,10,10-四甲基十二烷-2,11-二酮肟(HL91)在骨轉移瘤診斷中的應用價值.方法 27例骨痛患者,其中19例經病理檢查證實為骨轉移瘤(未行放化治療),8例為骨良性病變.所有患者均行99Tcm-亞甲基二膦痠鹽(MDP)顯像,2 d後註射99Tcm-HL91740 MBq,註射4 h後依據99Tcm-MDP顯示的病竈進行斷層顯像,利用感興趣區(ROI)技術,計算腫瘤與對側正常組織的放射性(T/N)比值.採用SPSS 11.0軟件進行t檢驗.結果 19例骨轉移患者99Tcm-MDP顯像提示的85處病竈,有79處99Tcm-HL91顯像呈異常放射性濃聚;經病理檢查或臨床證實的8例骨良性疾病中,99Tcm-MDP顯像提示的12處病竈99Tcm-HL91顯像全部呈陰性.HL91斷層顯像骨轉移組和骨良性疾病組的T/N比值分彆為1.877±0.288和0.735±0.236,差異有統計學意義(t=13.065,P＜0.05).肺癌、前列腺癌骨轉移病竈的T/N比值分彆為1.915±0.344和1.825±0.175,2種病理類型間差異無統計學意義(t=1.378,P＞0.05).結論 99Tcm-HL91顯像在骨骼良噁性病變的鑒彆中可能有一定價值.
목적 탐토핍양현상제99Tcm-4,9-이담-3,3,10,10-사갑기십이완-2,11-이동우(HL91)재골전이류진단중적응용개치.방법 27례골통환자,기중19례경병리검사증실위골전이류(미행방화치료),8례위골량성병변.소유환자균행99Tcm-아갑기이련산염(MDP)현상,2 d후주사99Tcm-HL91740 MBq,주사4 h후의거99Tcm-MDP현시적병조진행단층현상,이용감흥취구(ROI)기술,계산종류여대측정상조직적방사성(T/N)비치.채용SPSS 11.0연건진행t검험.결과 19례골전이환자99Tcm-MDP현상제시적85처병조,유79처99Tcm-HL91현상정이상방사성농취;경병리검사혹림상증실적8례골량성질병중,99Tcm-MDP현상제시적12처병조99Tcm-HL91현상전부정음성.HL91단층현상골전이조화골량성질병조적T/N비치분별위1.877±0.288화0.735±0.236,차이유통계학의의(t=13.065,P＜0.05).폐암、전렬선암골전이병조적T/N비치분별위1.915±0.344화1.825±0.175,2충병리류형간차이무통계학의의(t=1.378,P＞0.05).결론 99Tcm-HL91현상재골격량악성병변적감별중가능유일정개치.
Objective 99Tcm-4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime(HL91),a new type of hypoxic agents,accumulates in tumor hypoxic tissue specifically.The aim of this study was to evaluate the value of 99Tcm-HL91 imaging in the diagnosis of bone metastasis.Methods Nineteen cases with bone metastasis(without any treatment)and 8 cases with benign lesions underwent SPECT imaging at 4 h after injection of 740 MBq of 99Tcm-HL91 along with 99Tcm-methylene diphosphonic acid(MDP)imaging.Regions of interest(ROIs)were drawn in tumor tissue and contralateral normal tissue respectively,and the radioactivity ratios of tumor-to-normal(T/N)were calculated.The t-test was used for data analysis with SPSS 11.0.Results There were visible uptake of 99Tcm-HL91 in 79 out of 85 focuses in 19 patients of bone metastasis;however,there was no obvious uptake of 99Tcm-HL91 in 12 focuses of 8 patients of benign lesions.Significant difference existed between the T/N values of malignant(1.877±0.288)and benign lesions[(0.735±0.236);t=13.065,P＜0.05].However,the T/N value of bone metastasis from lung cancer did not differ with that from prostate cancer(1.915±0.344 and 1.825±0.175,respectively;t=1.378,P＞0.05).Conclusion The results indicated that 99Tcm-HL91 was useful in diagnosing the malignant and benign bone lesions.
