CAJ | 학술논문

目的探讨胃肠道间质瘤(gastrointestinal stromal tumors,GIST)首次术后复发转移的特点、治疗及预后因素.方法回顾性分析天津医科大学附属肿瘤医院和唐山市协和医院1997年1月至2007年12月首次手术后出现复发转移而就诊于两院的56例GIST病例的临床特点和治疗方法,并对其预后进行评价.结果本组56例发现复发转移的中位时间为17.3个月.单纯手术治疗19例,单纯靶向治疗8例,手术联合靶向治疗14例,3年生存率分别为65%、66%、89%.再次手术切除后的复发率为76%.单因素分析显示,预后与手术、靶向治疗及年龄有关(P＜0.05);多因素分析显示,手术和靶向治疗是预后的独立影响因素(P＜0.05).结论对于复发转移的GIST患者,手术联合靶向治疗能获得最佳的预后.
목적 탐토위장도간질류(gastrointestinal stromal tumors,GIST)수차술후복발전이적특점、치료급예후인소.방법 회고성분석천진의과대학부속종류의원화당산시협화의원1997년1월지2007년12월수차수술후출현복발전이이취진우량원적56례GIST병례적림상특점화치료방법,병대기예후진행평개.결과 본조56례발현복발전이적중위시간위17.3개월.단순수술치료19례,단순파향치료8례,수술연합파향치료14례,3년생존솔분별위65%、66%、89%.재차수술절제후적복발솔위76%.단인소분석현시,예후여수술、파향치료급년령유관(P＜0.05);다인소분석현시,수술화파향치료시예후적독립영향인소(P＜0.05).결론 대우복발전이적GIST환자,수술연합파향치료능획득최가적예후.
Objective To investigate the clinical characteristics, treatment and prognostic factors of postoperative recurrent-metastatic gastrointestinal stromal tumors (GIST). Methods The clinical data of 56 patients with postoperative recurrent-metastatic GIST between January 1997 and December 2007 were analyzed retrospectively , and the prognostic factors were evalutated. Results Initial recurrence-metastasis was diagnosed after a median of 17.3 months from primary resection. Of the 56 cases, 19 cases received resection, 8 cases received imatinib targeted therapy,14 cases were treated by imatinib targeted therapy and surgery, the 3 year survival rates were 65% ,66% ,89% respectively. The rate of recurrence-metastasis after reoperation is 76%. Univariate analysis revealed that surgery, targeted therapy and age were related to the survival rates, multivariate analysis demonstrated that surgery and targeted therapy were the independent prognostic factors for survival. Conclusions For recurrent-metastatic GIST, a multimodal approach including surgery and targeted therapy improves survival.