中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
15期
18-20
,共3页
尹治青%何忠友%袁振飞%王蓓蓓%钱锐锋%王艳红
尹治青%何忠友%袁振飛%王蓓蓓%錢銳鋒%王豔紅
윤치청%하충우%원진비%왕배배%전예봉%왕염홍
高频喷射通气%单肺通气%氧化应激
高頻噴射通氣%單肺通氣%氧化應激
고빈분사통기%단폐통기%양화응격
High-frequency jet ventilation%One-lung ventilation%Oxidative stress
目的 研究高频喷射通气(HFJV)对单肺通气患者氧化应激反应的影响.方法 择期行食管癌根治术患者45例,按随机数字表法分为双肺通气组(A组)、单肺通气组(B组)、单肺通气时非通气侧给予HFJV(驱动压力1 kg/cm2,频率100次/min)组(C组),每组15例.分别于开胸前(T0),单肺通气后(A组于开胸后)30 min(T1)、90 min(T2)、150 min(T3),手术结束时(T4)测定超氧化物歧化酶(SOD)活性及丙二醛(MDA)、一氧化氮(NO)浓度.结果 T2～T4时B、C组SOD活性[B组:(47±10)、(37±9)、(41±7)kU/L;C组:(58±12)、(51±11)、(49±9)kU/L]低于A组[(78±8)、(75±7)、(79±6)kU/L](P＜0.05),T1～T4时B、C组MDA、NO浓度高于A组(P＜0.05);T3时C组SOD活性明显高于B组(P＜0.05),T1～T4时C组MDA浓度及T2～T4时NO浓度低于B组(P＜0.05).结论 HFJV能在一定程度上抑制单肺通气患者的氧化应激反应.
目的 研究高頻噴射通氣(HFJV)對單肺通氣患者氧化應激反應的影響.方法 擇期行食管癌根治術患者45例,按隨機數字錶法分為雙肺通氣組(A組)、單肺通氣組(B組)、單肺通氣時非通氣側給予HFJV(驅動壓力1 kg/cm2,頻率100次/min)組(C組),每組15例.分彆于開胸前(T0),單肺通氣後(A組于開胸後)30 min(T1)、90 min(T2)、150 min(T3),手術結束時(T4)測定超氧化物歧化酶(SOD)活性及丙二醛(MDA)、一氧化氮(NO)濃度.結果 T2～T4時B、C組SOD活性[B組:(47±10)、(37±9)、(41±7)kU/L;C組:(58±12)、(51±11)、(49±9)kU/L]低于A組[(78±8)、(75±7)、(79±6)kU/L](P＜0.05),T1～T4時B、C組MDA、NO濃度高于A組(P＜0.05);T3時C組SOD活性明顯高于B組(P＜0.05),T1～T4時C組MDA濃度及T2～T4時NO濃度低于B組(P＜0.05).結論 HFJV能在一定程度上抑製單肺通氣患者的氧化應激反應.
목적 연구고빈분사통기(HFJV)대단폐통기환자양화응격반응적영향.방법 택기행식관암근치술환자45례,안수궤수자표법분위쌍폐통기조(A조)、단폐통기조(B조)、단폐통기시비통기측급여HFJV(구동압력1 kg/cm2,빈솔100차/min)조(C조),매조15례.분별우개흉전(T0),단폐통기후(A조우개흉후)30 min(T1)、90 min(T2)、150 min(T3),수술결속시(T4)측정초양화물기화매(SOD)활성급병이철(MDA)、일양화담(NO)농도.결과 T2～T4시B、C조SOD활성[B조:(47±10)、(37±9)、(41±7)kU/L;C조:(58±12)、(51±11)、(49±9)kU/L]저우A조[(78±8)、(75±7)、(79±6)kU/L](P＜0.05),T1～T4시B、C조MDA、NO농도고우A조(P＜0.05);T3시C조SOD활성명현고우B조(P＜0.05),T1～T4시C조MDA농도급T2～T4시NO농도저우B조(P＜0.05).결론 HFJV능재일정정도상억제단폐통기환자적양화응격반응.
Objective To determine the effects of high-frequency jet ventilation (HFJV) on oxidative stress in patients during one-lung ventilation (OLV). Methods Forty-five patients undergoing elective radical esophageal cancer resection were divided into three groups with 15 cases each by random digits table: two lung ventilation group ( group A), OLV group (group B), HFJV- OLV group ( group C, working pressure 1 kg/cm2 and frequency 100 times/min). Venous blood samples were taken before induction (T0),at30min (T1),90min (T2),150min (T3) after OLV and the end of operation (T4) for measuring serum superoxide dismutase(SOD),malondialdehyde (MDA) and nitric oxide (NO). Results SOD was lower at T2-T4 in group B[(47 ± 10), (37 ±9), (41 ±7) kU/L] and group C[(58 ± 12), (51 ± 11), (49 ± 9) kU/L] than those in group A [(78 ±8), (75 ±7), (79 ±6) kU/L](P＜ 0.05),and MDA and NO were lower at T1-T4 in group B and group C than that in group A(P＜ 0.05). SOD was higher at T3 in group C than that in group B (P ＜ 0.05), MDA at T1-T4 and NO at T2-T4 were lower in group C than those in group B (P ＜ 0.05). Conclusion HFJV can effectively decrease oxidative stress in patients during OLV.
