CAJ | 학술논문

目的探讨以明胶凉尼平粘合自体颗粒骨修复SD大鼠胫骨骨缺损的效果.方法取60只SD大鼠制备右侧胫骨上端骨缺损模型,并将切除的骨质磨成颗粒骨,随机分为四组(n=15),A组为空白组不填充任何材料,B组单纯填充明胶、京尼平,C组单纯植入自体颗粒骨,D组填充明胶、京尼平和自体颗粒骨.各组术后10 d、4周和8周时各处死大鼠5只,取材检测,通过观察大体标本、X线片及组织学检查评估骨缺损修复能力. 结果在术后各时期,从大体观察、X线检测及组织学观察结果表明C、D组均有良好的骨修复效果,A、B组的骨修复效果相似但明显差于C、D组.材料植入10 d时,D组复合物表面均形成明显的纤维包裹,植入物不会再移动,打开包膜后,材料均可被夹起而不散开,C组颗粒骨有部分移位于周围软组织间隙. 结论明胶、京尼平具有粘合自体颗粒骨修复骨缺损的能力.
목적 탐토이명효량니평점합자체과립골수복SD대서경골골결손적효과.방법 취60지SD대서제비우측경골상단골결손모형,병장절제적골질마성과립골,수궤분위사조(n=15),A조위공백조불전충임하재료,B조단순전충명효、경니평,C조단순식입자체과립골,D조전충명효、경니평화자체과립골.각조술후10 d、4주화8주시각처사대서5지,취재검측,통과관찰대체표본、X선편급조직학검사평고골결손수복능력. 결과 재술후각시기,종대체관찰、X선검측급조직학관찰결과 표명C、D조균유량호적골수복효과,A、B조적골수복효과상사단명현차우C、D조.재료식입10 d시,D조복합물표면균형성명현적섬유포과,식입물불회재이동,타개포막후,재료균가피협기이불산개,C조과립골유부분이위우주위연조직간극. 결론 명효、경니평구유점합자체과립골수복골결손적능력.
Objective To explore the effects of repairing the tibial bone defects in SD rats with different compounds of gelatin, genipin and autogenous morselized bone. Methods Sixty SD rats were randomized into 4 equal groups. A segmental bone defect was created at the right tibia in each rat. The dis-sected bone segments were moralized into bone particles. Group A served as blank control without any fillings into the defects. In Group B, the compound of gelatin and genipin was used as filling; in Group C, the compound of 200 mg autogenous morselized bone was grafted; in Group D, the compound of gelatin, genipin and 100 nag autogenous morselized bone was grafted. The defect-repairing capability in each group was as-sessed by gross observation and X-ray and histological examinations at 10 days, 4 weeks and 8 weeks after operation. Results At deferent times after operation, the effects of bone-repairing in Groups C and D were significantly superior to those in Groups A and B. At 10 days after operation, fibers were seen wrapping the surface of autogenous morselized bone and the graft was immobilized in Group D. Some particles of auto-genous morselized bone were seen shifting into the nearby soft tissue in Group C. Conclusion The gelatin and genipin can paste the autogenous morselized bone particles to repair bone defects.