CAJ | 학술논문

研究糖尿病患者血清血管内皮细胞钙黏蛋白(VE-cadherin)、晚期糖基化终产物(AGE)与糖尿病大血管病变的关系.设健康对照组20例,糖尿病患者60例,其中伴颈动脉粥样硬化组30例,采用ELISA法测定各组血清可溶性VE-cadherin、AGE,并与病程、血糖水平进行多元逐步回归分析.糖尿病组与颈动脉粥样硬化组的VE-cadherin、AGE水平均高于对照组(均P＜0.05),糖尿病组与颈动脉粥样硬化组之间VE-cadherin差异有统计学意义(P＜0.05).VE-cadherin水平与AGE显著正相关(r=0.69,P＜0.01),AGE与糖尿病病程呈正相关(r=0.31,P=0.02).糖尿病患者血清中可溶性VE-cadherin水平与AGE相关,推测VE-cadherin可能是AGE致动脉粥样硬化的靶点和重要环节.
연구당뇨병환자혈청혈관내피세포개점단백(VE-cadherin)、만기당기화종산물(AGE)여당뇨병대혈관병변적관계.설건강대조조20례,당뇨병환자60례,기중반경동맥죽양경화조30례,채용ELISA법측정각조혈청가용성VE-cadherin、AGE,병여병정、혈당수평진행다원축보회귀분석.당뇨병조여경동맥죽양경화조적VE-cadherin、AGE수평균고우대조조(균P＜0.05),당뇨병조여경동맥죽양경화조지간VE-cadherin차이유통계학의의(P＜0.05).VE-cadherin수평여AGE현저정상관(r=0.69,P＜0.01),AGE여당뇨병병정정정상관(r=0.31,P=0.02).당뇨병환자혈청중가용성VE-cadherin수평여AGE상관,추측VE-cadherin가능시AGE치동맥죽양경화적파점화중요배절.
To investigate the relationship among serum vascular endothelial cells(VE) -cadherin, advanced glycation end-products( AGE), and atherosclerotic lesion. 20 healthy subjects and 60 patients with diabetes mellitus,including 30 patients with carotid atherosclerosis (CI), were enrolled. Soluble VE-cadherin and AGE were determined using the enzyme-linked immunosorbent method (ELISA). The relationships among the concentration of soluble VE-cadherin, AGE, and the course of the disease, blood glucose, and blood lipid levels were analyzed with multivariant stepwise regression analysis. The levels of serum VE-cadherin and AGE in the patients with diabetes and CI were higher than those in control group( P＜0. 05 ). There was a significant difference in VE-cadherin between the diabetes group and the CI group( P＜0. 05 ). Serum VE-cadherin levels were positively correlated with serum AGE levels(r = 0. 69, P＜0. 01 ). AGE levels were positively correlated with the diabetes duration ( r = 0. 31, P =0. 02 ). The levels of serum VE-cadherin in diabetic patients are positively correlated with their serum AGE levels. The VE-cadherin seems to play an important role in the development of atherosclerosis caused by AGE.