CAJ | 학술논문

目的探讨脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)基因Val66Met多态性与首发精神分裂症临床特征的关联性.方法应用TaqMan荧光探针技术对135例首发精神分裂症患者及483名正常对照者进行基因分型；采用阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评估精神分裂症患者临床特征.结果精神分裂症患者组与正常对照组BDNF Val66Met基因型及等位基因分布频率的差异具有统计学意义(P＜0.01);Met/Met基因型患者的PANSS总分、焦虑(抑郁)因子分及认知损害因子分均高于Val/Val和Val/Met基因型患者,差异有统计学意义(P＜0.01).结论 BDNF基因Val66Met多态性可能与精神分裂症的发病有关；首发精神分裂症患者中Met/Met基因型者临床症状可能更重.
목적 탐토뇌원성신경영양인자(brain-derived neurotrophic factor,BDNF)기인Val66Met다태성여수발정신분렬증림상특정적관련성.방법 응용TaqMan형광탐침기술대135례수발정신분렬증환자급483명정상대조자진행기인분형；채용양성여음성증상량표(positive and negative syndrome scale,PANSS)평고정신분렬증환자림상특정.결과 정신분렬증환자조여정상대조조BDNF Val66Met기인형급등위기인분포빈솔적차이구유통계학의의(P＜0.01);Met/Met기인형환자적PANSS총분、초필(억욱)인자분급인지손해인자분균고우Val/Val화Val/Met기인형환자,차이유통계학의의(P＜0.01).결론 BDNF기인Val66Met다태성가능여정신분렬증적발병유관；수발정신분렬증환자중Met/Met기인형자림상증상가능경중.
Objective To assess the association between brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism and clinical characteristics of first episode schizophrenia in a Chinese Han population.Methods Genotyping of BDNF Val66Met polymorphism was carried out for 135 schizophrenic patients and 483 healthy controls with TaqMan probe technology.The patients' psychotic symptoms were assessed using the positive and negative syndrome scale (PANSS).Results A significant difference was found in genotype distribution and allelic frequency of the Val66Met polymorphism between the two groups (P＜0.01).In patients,Met homozygotes had a significantly higher score in anxiety/depression factor,cognitive factor and total score of PANSS than Val carriers: Conclusion BDNF gene Val66Met polymorphism is associated with the pathogenesis of schizophrenia.The Met/Met genotype of BDNF Val66Met variant may be a risk factor for symptoms in first episode schizophrenia patients.