CAJ | 학술논문

整合素主要介导细胞与细胞、细胞与细胞外基质(ECM)之间的相互黏附,对细胞的黏附、增殖、分化、转移、凋亡起到重要的调控作用,在肿瘤的侵袭转移中发挥重要作用.成熟血管内皮细胞和绝大多数正常器官系统中,整合素αvβ3受体表达缺乏或几乎不能被探及,但其在新生血管内皮细胞中有强烈表达,精氨酸-甘氨酸-天冬氨酸(RGD)肽是整合素αvβ3受体的特异性识别位点,因此,将放射性核素标记到含有RGD序列的肽类化合物上,用于整合素αvβ3受体显像,对于肿瘤早期和高特异性定位、定量诊断及治疗都具有重要意义.近年来国内外对RGD肽的标记方法和αvβ3受体显像进行了研究.
정합소주요개도세포여세포、세포여세포외기질(ECM)지간적상호점부,대세포적점부、증식、분화、전이、조망기도중요적조공작용,재종류적침습전이중발휘중요작용.성숙혈관내피세포화절대다수정상기관계통중,정합소αvβ3수체표체결핍혹궤호불능피탐급,단기재신생혈관내피세포중유강렬표체,정안산-감안산-천동안산(RGD)태시정합소αvβ3수체적특이성식별위점,인차,장방사성핵소표기도함유RGD서렬적태류화합물상,용우정합소αvβ3수체현상,대우종류조기화고특이성정위、정량진단급치료도구유중요의의.근년래국내외대RGD태적표기방법화αvβ3수체현상진행료연구.
The malignant tumors must establish a neovasculature to grow,to invade,and to memsmsize,in which αvβ3 integrin plays an important role.It is reported that the αvβ3 integrin made their effeetion mainly by binding triplet peptides RGD sequence in the proteins of the extraceUular matrix.Because is reported to there is no or rare αvβ3 integrin in normal ceils but more in activated endothelial cells,RGD is the special target point for αvβ3 Integrin.RGD antagonistic peptides radiolabelled by direct or indirect way could be used to display tumor αvβ3 Integrin by nuclear medicine image.It is of significance to locate and quantitate tumor Integrin hish special in early diagnosis and therapy.This article reviews the marking method of RGD peptide and study about the image of αvβ3 receptor.