中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
1期
4-6
,共3页
糖尿病神经病变%硫辛酸%度洛西汀
糖尿病神經病變%硫辛痠%度洛西汀
당뇨병신경병변%류신산%도락서정
Diabetic neuropathies%Thioctic acid%Duloxetine
目的 探讨度洛西汀联合硫辛酸治疗糖尿病痛性神经病变的临床效果.方法 将62例糖尿病痛性神经病变患者按照随机数字表法分为三组:A组22例用度洛西汀联合硫辛酸治疗,B、C组各20例分别用度洛西汀和硫辛酸治疗;其他治疗方案相同.疗程均为6周.比较三组患者治疗前后疼痛缓解程度及神经传导速度的变化.结果 A、B、C组患者治疗后疼痛均有明显改善(P＜0.01);总有效率分别为86.4%(19/22)、70.0%(14/20)、50.0%(10/20),差异有统计学意义(P＜0.05);从治疗后2周开始A组视觉模拟评分(VAS)明显低于B组和C组(P＜0.05);A、C组神经传导速度均有改善,与治疗前比较差异有统计学意义(P＜0.01);但治疗后A、C组神经传导速度比较差异无统计学意义(P＞0.05);B组治疗前后神经传导速度比较差异无统计学意义(P＞0.05).结论 度洛西汀联合硫辛酸可提高治疗糖尿病痛性神经病变的临床效果.
目的 探討度洛西汀聯閤硫辛痠治療糖尿病痛性神經病變的臨床效果.方法 將62例糖尿病痛性神經病變患者按照隨機數字錶法分為三組:A組22例用度洛西汀聯閤硫辛痠治療,B、C組各20例分彆用度洛西汀和硫辛痠治療;其他治療方案相同.療程均為6週.比較三組患者治療前後疼痛緩解程度及神經傳導速度的變化.結果 A、B、C組患者治療後疼痛均有明顯改善(P＜0.01);總有效率分彆為86.4%(19/22)、70.0%(14/20)、50.0%(10/20),差異有統計學意義(P＜0.05);從治療後2週開始A組視覺模擬評分(VAS)明顯低于B組和C組(P＜0.05);A、C組神經傳導速度均有改善,與治療前比較差異有統計學意義(P＜0.01);但治療後A、C組神經傳導速度比較差異無統計學意義(P＞0.05);B組治療前後神經傳導速度比較差異無統計學意義(P＞0.05).結論 度洛西汀聯閤硫辛痠可提高治療糖尿病痛性神經病變的臨床效果.
목적 탐토도락서정연합류신산치료당뇨병통성신경병변적림상효과.방법 장62례당뇨병통성신경병변환자안조수궤수자표법분위삼조:A조22례용도락서정연합류신산치료,B、C조각20례분별용도락서정화류신산치료;기타치료방안상동.료정균위6주.비교삼조환자치료전후동통완해정도급신경전도속도적변화.결과 A、B、C조환자치료후동통균유명현개선(P＜0.01);총유효솔분별위86.4%(19/22)、70.0%(14/20)、50.0%(10/20),차이유통계학의의(P＜0.05);종치료후2주개시A조시각모의평분(VAS)명현저우B조화C조(P＜0.05);A、C조신경전도속도균유개선,여치료전비교차이유통계학의의(P＜0.01);단치료후A、C조신경전도속도비교차이무통계학의의(P＞0.05);B조치료전후신경전도속도비교차이무통계학의의(P＞0.05).결론 도락서정연합류신산가제고치료당뇨병통성신경병변적림상효과.
Objective To investigate the clinical curative effects of duloxetine combined with thioctic acid on diabetic painful peripheral neuropathy. Methods Sixty-two patients with diabetic painful peripheral neuropathy were divided into three groups by random digits table: group A(22 patients, duloxetine combined with thioctic acid group), group B (20 patients,duloxetine group) and group C (20 patients,thioctic acid group). The other treatments were same. All patients were treated for six weeks. The pain remission level and nerve conductive velocity were compared among three groups. Results The pain level in three groups was significantly alleviated after treatment (P ＜ 0.01 ). The general effective rate was 86.4%(19/22),70.0% (14/20) and 50.0% (10/20) in group A,group B and group C,respectively (P ＜ 0.05). Visual analogue scales (VAS) in group A was significantly lower than that in group B and group C from the second week after treatment (P ＜ 0.05 ). Nerve conductive velocity was improved in both group A and group C after treatment (P＜0.01),but there was no significant difference between two groups (P＞0.05). In group B,compared with that before treatment,nerve conductive velocity had no significantly improved after treatment (P＞ 0.05). Conclusion Duloxetine combined with thioctic acid can enhance the clinical curative effects on diabetic painful peripheral neuropathy.
