CAJ | 학술논문

目的探讨血清肿瘤标志物癌抗原15-3(CA15-3)、细胞角蛋白19片段抗原(CYFRA21-1)联合彩色多普勒超声及钼靶X线对早期乳腺癌诊断的临床应用价值.方法选取106例乳腺癌患者(乳腺癌组)和50例乳腺良性病变患者(对照组),将患者血清CA15-3、CYFRA21-1、彩色多普勒超声和钼靶X线检查资料与手术后病理对照,进行回顾性分析.结果 CA15-3对早期乳腺癌诊断的敏感度为63.2%(67/106),特异度为94.0%(47/50);CYFRA21-1敏感度为73.6%(78/106),特异度为88.0%(44/50);彩色多普勒超声敏感度为77.4%(82/106),特异度为90.0%(45/50);钼靶X线敏感度为75.5%(80/106),特异度为92.0%(46/50).四项联合检查敏感度高达96.2%(102/106),特异度为80.0%(40/50),敏感度与各单项检查相比差异有统计学意义(P<0.05).结论应用联合诊断法诊断早期乳腺癌是发现乳腺癌的有效途径,具有较高的阳性检出率和可靠的临床指导意义.
목적 탐토혈청종류표지물암항원15-3(CA15-3)、세포각단백19편단항원(CYFRA21-1)연합채색다보륵초성급목파X선대조기유선암진단적림상응용개치.방법 선취106례유선암환자(유선암조)화50례유선량성병변환자(대조조),장환자혈청CA15-3、CYFRA21-1、채색다보륵초성화목파X선검사자료여수술후병리대조,진행회고성분석.결과 CA15-3대조기유선암진단적민감도위63.2%(67/106),특이도위94.0%(47/50);CYFRA21-1민감도위73.6%(78/106),특이도위88.0%(44/50);채색다보륵초성민감도위77.4%(82/106),특이도위90.0%(45/50);목파X선민감도위75.5%(80/106),특이도위92.0%(46/50).사항연합검사민감도고체96.2%(102/106),특이도위80.0%(40/50),민감도여각단항검사상비차이유통계학의의(P<0.05).결론 응용연합진단법진단조기유선암시발현유선암적유효도경,구유교고적양성검출솔화가고적림상지도의의.
Objective To investigate the clinical value of serum tumor makers CA15-3,19 fragments of cellular keratin antigen(CYFRA21-1)combined with the color Doppler ultrasound and mammography X-ray in diagnosis of early breast cancer.Methods According to the postoperative pathologic diagnosis,collected 106 cases of patients with breast cancer (breast cancer group) and 50 cases of patients with benign breast lesions (control group),the serum tumor makers CA15-3,CYFRA21-1,the color Doppler ultrasound and mammography X-ray were compared with postoperative pathology and statistical analyzed retrospectively.Results The sensitivity of CA15-3 was 63.2%(67/106),specificity was 94.O% (47/50);the sensitivity of CYFRA21-1 was 73.6%(78/106),specificity was 88.0%(44/50);the sensitivity of color Doppler ultrasound was 77.4%(82/106),specificity was 90.0%(45/50);the sensitivity of mammography X-ray was 75.5%(80/106),specificity was 92.0%(46/50);the sensitivity of the four combined detections was 96.2%(102/106),specificity was 80.0%(40/50).The sensitivity of combined detection was higher than any of them individually,there was statistical significance (P<0.05).Conclusions Combined diagnosis is an effective way of early breast cancer detection.It has high positive rate of diagnosis and reliable guidance significance for diagnosis and treatment.