CAJ | 학술논문

用免疫组化和RT-PCR方法检测糖尿病大鼠肾组织中Toll样受体4(TLR4)的表达.结果显示糖尿病组TLR4表达较正常对照组升高(P＜0.05),而辛伐他汀干预组较糖尿病组低(P＜0.05),提示TLR4可能参与了糖尿病肾病的发生及发展.辛伐他汀可能通过降低TLR4的表达保护肾组织.
용면역조화화RT-PCR방법검측당뇨병대서신조직중Toll양수체4(TLR4)적표체.결과현시당뇨병조TLR4표체교정상대조조승고(P＜0.05),이신벌타정간예조교당뇨병조저(P＜0.05),제시TLR4가능삼여료당뇨병신병적발생급발전.신벌타정가능통과강저TLR4적표체보호신조직.
Immunohistocheraistry and RT-PCR were used to examine the expression of toll-like receptor 4 (TLR4) in the kidney of diabetic rats.Compared with normal control group,the expression of TLR4 in diabetes mellitus group was increased ( P ＜ 0.05 ).Compared with diabetes mellitus group,the expression of TLR4 in simvastatin treated group was decreased( P＜0.05 ).The results suggest that TLR4 may play a role in the pathogenesis of diabetic nephropathy.Simvastatin seems to delay the progress of diabetic nephropathy via reducing TLR4 expression.