CAJ | 학술논문

目的评价不同疗程胰岛素强化治疗对口服降糖药治疗失效的2型糖尿病患者胰岛β细胞功能的保护作用.方法 64例口服降糖药治疗失效的2型糖尿病患者按胰岛素强化治疗疗程分成3组,10 d组20例,30 d组22例,60 d组22例.计算胰岛素强化治疗期间胰岛素使用日最大剂量和最后一天血糖达标时剂量,计算3组β细胞功能指数和胰岛素抵抗指数.结果 30 d组和60 d组在疗程结束时,血糖达标的胰岛素基础量和餐前量均较10 d组少;60 d组平均胰岛素日用量为(1.1±0.14)U/(kg·d),显著低于10 d组[(1.6±0.12)u/(kg·d)];3组糖化血红蛋白均较治疗前下降,以60 d组最显著.1年后60 d组有68%单用口服降糖药即可有效控制血糖.结论胰岛素强化治疗60 d更有利于口服降糖药失效的2型糖尿病患者β细胞功能的改善.
목적 평개불동료정이도소강화치료대구복강당약치료실효적2형당뇨병환자이도β세포공능적보호작용.방법 64례구복강당약치료실효적2형당뇨병환자안이도소강화치료료정분성3조,10 d조20례,30 d조22례,60 d조22례.계산이도소강화치료기간이도소사용일최대제량화최후일천혈당체표시제량,계산3조β세포공능지수화이도소저항지수.결과 30 d조화60 d조재료정결속시,혈당체표적이도소기출량화찬전량균교10 d조소;60 d조평균이도소일용량위(1.1±0.14)U/(kg·d),현저저우10 d조[(1.6±0.12)u/(kg·d)];3조당화혈홍단백균교치료전하강,이60 d조최현저.1년후60 d조유68%단용구복강당약즉가유효공제혈당.결론 이도소강화치료60 d경유리우구복강당약실효적2형당뇨병환자β세포공능적개선.
Objective To evaluate the effect of different courses of intensive insulin therapy on protection of pancreatic β-cell function in oral hypoglycemic agent failed type 2 diabetes (T2DM). Methods According to cour-ses of intensive insulin therapy, 64 patients with OHA failed T2DM were divided into group A(20 cases,10 days), group B (22 cases, 30 days)and group C (22 cases, 60 days). Results At the end of different courses, the daily administration of basic dose and premeal supplementary dose of insulin at target blood glucose level in group B and C were lower than group A. The average dose of total daily insulin in group C was significantly lower than that in group A. The insulin secretion and C-peptide secretion was significantly improved in group B and C. Glycosylated hemo-globin decreased in all groups, most significantly in group C(P<0.05). After 1 year, blood glucose level was ef-fectively controlled by oral hypoglycemic agents alone in 61% cases of group B and 68% of group C. Conclusion Sixty days of intensive insulin therapy is effective to recover β-cell function in with OHA failed T2DM patients.