中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
4期
8-10
,共3页
韦宁%韦英海%黎彬如%欧世宁
韋寧%韋英海%黎彬如%歐世寧
위저%위영해%려빈여%구세저
半胱氨酸%脑梗塞%丁苯酞
半胱氨痠%腦梗塞%丁苯酞
반광안산%뇌경새%정분태
Cysteine%Brain infarction%Butylphthalide
目的 研究丁苯酞对急性脑梗死患者同型半胱氨酸(Hcy)和C反应蛋白(CRP)水平的影响.方法 将110例急性脑梗死患者按随机数字表法分为对照组和治疗组,对照组55例给予常规治疗,治疗组55例在常规治疗的基础上加用丁苯酞200 mg口服,3次/d,两组均治疗3周.比较两组患者的总有效率、神经功能缺损评分、Hcy和CRP水平.结果 治疗组总有效率为89.09％(49/55),对照组为61.82％( 34/55),两组比较差异有统计学意义(x2=11.044,P＜0.01).两组治疗后神经功能缺损评分均较治疗前降低[治疗组:(11.24±3.19)分比(23.19±4.06)分,对照组:(18.56±4.03)分比(22.31±4.17)分,P＜0.01],且治疗组治疗后神经功能缺损评分低于同期对照组,差异有统计学意义(P＜0.01).两组患者治疗后Hcy、CRP水平较治疗前显著降低[治疗组:(13.12±3.58)μmol/L比(27.36±6.84)μmol/L,(10.33±3.10) mg/L比(18.96±5.38) mg/L;对照组:(16.41±4.76)μmol/L比(28.73±6.32)μmol/L,(13.16±4.02) mg/L比(19.17±5.74) mg/L,P＜0.01],并且治疗组治疗后Hcy、CRP水平显著低于同期对照组(P＜0.01).结论 丁苯酞可降低急性脑梗死患者Hcy和CRP水平,减轻炎性反应,改善急性脑梗死患者病情.
目的 研究丁苯酞對急性腦梗死患者同型半胱氨痠(Hcy)和C反應蛋白(CRP)水平的影響.方法 將110例急性腦梗死患者按隨機數字錶法分為對照組和治療組,對照組55例給予常規治療,治療組55例在常規治療的基礎上加用丁苯酞200 mg口服,3次/d,兩組均治療3週.比較兩組患者的總有效率、神經功能缺損評分、Hcy和CRP水平.結果 治療組總有效率為89.09％(49/55),對照組為61.82％( 34/55),兩組比較差異有統計學意義(x2=11.044,P＜0.01).兩組治療後神經功能缺損評分均較治療前降低[治療組:(11.24±3.19)分比(23.19±4.06)分,對照組:(18.56±4.03)分比(22.31±4.17)分,P＜0.01],且治療組治療後神經功能缺損評分低于同期對照組,差異有統計學意義(P＜0.01).兩組患者治療後Hcy、CRP水平較治療前顯著降低[治療組:(13.12±3.58)μmol/L比(27.36±6.84)μmol/L,(10.33±3.10) mg/L比(18.96±5.38) mg/L;對照組:(16.41±4.76)μmol/L比(28.73±6.32)μmol/L,(13.16±4.02) mg/L比(19.17±5.74) mg/L,P＜0.01],併且治療組治療後Hcy、CRP水平顯著低于同期對照組(P＜0.01).結論 丁苯酞可降低急性腦梗死患者Hcy和CRP水平,減輕炎性反應,改善急性腦梗死患者病情.
목적 연구정분태대급성뇌경사환자동형반광안산(Hcy)화C반응단백(CRP)수평적영향.방법 장110례급성뇌경사환자안수궤수자표법분위대조조화치료조,대조조55례급여상규치료,치료조55례재상규치료적기출상가용정분태200 mg구복,3차/d,량조균치료3주.비교량조환자적총유효솔、신경공능결손평분、Hcy화CRP수평.결과 치료조총유효솔위89.09％(49/55),대조조위61.82％( 34/55),량조비교차이유통계학의의(x2=11.044,P＜0.01).량조치료후신경공능결손평분균교치료전강저[치료조:(11.24±3.19)분비(23.19±4.06)분,대조조:(18.56±4.03)분비(22.31±4.17)분,P＜0.01],차치료조치료후신경공능결손평분저우동기대조조,차이유통계학의의(P＜0.01).량조환자치료후Hcy、CRP수평교치료전현저강저[치료조:(13.12±3.58)μmol/L비(27.36±6.84)μmol/L,(10.33±3.10) mg/L비(18.96±5.38) mg/L;대조조:(16.41±4.76)μmol/L비(28.73±6.32)μmol/L,(13.16±4.02) mg/L비(19.17±5.74) mg/L,P＜0.01],병차치료조치료후Hcy、CRP수평현저저우동기대조조(P＜0.01).결론 정분태가강저급성뇌경사환자Hcy화CRP수평,감경염성반응,개선급성뇌경사환자병정.
Objective To study the effects of butylphthalide on homocysteine (Hcy) and C-reactive protein (CRP) levels in patients with acute cerebral infarction.Methods One hundred and ten patients with acute cerebral infarction were divided into control group and treatment group by random digits table,with 55 patients in each group.Two groups were given conventional treatment for 3 weeks,and treatment group was added butylphthalide 200 mg oral application,thrice a day.Two groups were compared in the total effective rate,neurological deficit scores (NDS) and serum Hcy and CRP levels.Results The total effective rate in treatment group was significantly higher than that in control group [ 89.09％ (49/55) vs.61.82％ (34/55),x2 =11.044,P＜ 0.01 ].The NDS in two groups after treatment were significantly decreased than those before treatment [treatment group:( 11.24 ± 3.19) scores vs.(23.19 ± 4.06) scores,control group:( 18.56 ± 4.03 )scores vs. (22.31 ± 4.17) scores,P ＜ 0.01 ],and NDS in treatment group after treatment was significantly lower than that in control group (P＜ 0.01 ).The serum Hcy and CRP levels in two groups after treatment were significantly lower than those before treatment [ treatment group:( 13.12 ± 3.58 ) μ mol/L vs.(27.36 ± 6.84 )μ mol/L,( 10.33 ± 3.10) mg/L vs.( 18.96 ± 5.38) mg/L;control group:( 16.41 ± 4.76) μ mol/L vs.(28.73 ±6.32) μ mol/L,(13.16±4.02) mg/L vs. (19.17 ± 5.74) mg/L,P ＜ 0.01 ],serum Hcy and CRP levels in treatment group after treatment were significantly lower than those in control group (P ＜ 0.01 ).Conclusion Butylphthalide can reduce serum Hcy and CRP levels,reduce inflammation and improve the condition of patients with acute cerebral infarction.
